Diabetes and Heart Disease Risk in Blacks
关键词
抽象
描述
This study is designed to investigate in blacks the relationship of risk for diabetes and heart disease from obesity plasma glucose and triglyceride concentrations and the triglyceride related risk factors of small dense low density lipoprotein (LDL), high density lipoprotein (HDL) and central obesity.
The Framingham Study demonstrated that obesity and elevated glucose and triglyceride levels are important risk factors for coronary artery disease in white women. However, studies that have had significant participation of black women such as the Charleston Heart Study, failed to show a relationship of obesity or triglyceride to coronary artery disease mortality in black women. In fact, black women independent of body weight or triglyceride levels experience high mortality from coronary artery disease. Our earlier research has demonstrated that obese black men have elevated triglyceride levels but obese black women have normal triglyceride levels. Consequently if elevated triglyceride levels do not occur in obese nondiabetic black women, then elevated triglyceride levels may not represent a major cardiovascular risk for black women.
The study, Diabetes and Heart Disease Risk in Blacks, is designed to determine the role of obesity, glucose and triglyceride on risk for heart disease in blacks. For this study of blacks, we will study 2 groups, African Americans and Black Africans living in the United States. African Americans must self-identify as African American, be born in the United States and have parents who self-identify as African American and were born in the United States. The second group will be blacks living in the United States but were born in Africa and whose parents were born in Africa.
We will recruit 1132 healthy, non-diabetic individuals (546 men, 586 women), age range 18-65, and body mass index (3 subgroups: nonobese, overweight and obese). We need to recruit more women than men because triglyceride and glucose levels are lower in women than men. Therefore a larger number of women are needed to see an effect. In 2 outpatient visits to the Clinical Center, participants will have body fat analyses, an electrocardiogram, an oral glucose tolerance test, questionnaires about sleep and stress and an intravenous glucose tolerance test. This study has the potential to provide significant insight and lead to the development of programs that help decrease diabetes and cardiovascular risk in blacks.
日期
| 最后验证: | 10/14/2020 |
| 首次提交: | 11/02/1999 |
| 提交的预估入学人数: | 11/02/1999 |
| 首次发布: | 11/03/1999 |
| 上次提交的更新: | 11/03/2020 |
| 最近更新发布: | 11/04/2020 |
| 实际学习开始日期: | 10/20/1998 |
状况或疾病
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Healthy Volunteers Healthy adult African Americans born in the United States, with American born parents or born in Africa with African born parents. |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 取样方式 | Non-Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | - INCLUSION CRITERIA: Ethnicity: African Americans To enroll participants must self-identify as African Americans and be born in the United States, with American born parents or be born in Africa with African born parents. In the future, we plan to expand the study to include other groups which self-identify as African Americans (i.e. AfroCarribeans and Hispanic blacks). Age: The age range of the participants will be between 18 and 50 years. Medical History: To participate in the study subjects should identify themselves as healthy. Menstrual History: Women must give a history of regular monthly cycles (24-35 days) for at least one year. EXCLUSION CRITERIA: African American Ethnicity other than American or West African ancestry. In the future, we will expand the study to include other African American groups such as individuals of Afro-Caribbean and Hispanic blacks. Medications: People who take medications that are known to alter the parameters which are under investigation in this study will be excluded. An example would be medications used to treat hyperlipidemia such as statins, niacin, bile acid sequestrants and fibric acid derivatives. Subjects on thyroid hormone replacement will be included if their TSH is normal. Diabetes: Because diabetes affects insulin sensitivity and TG levels all people with diabetes even if the diabetes is controlled with diet alone will not be enrolled in the study. Breastfeeding: Women who are breastfeeding or have an infant that is less than four months of age will be excluded. This is because the physiologic changes associated with breastfeeding or recent childbirth affect the parameters under study. Menstrual History: Women with a history of irregular menstrual cycles in the year prior to the study will be excluded. Due to the requirement for regular menses, women in the following categories, regardless of age will be excluded: history of hysterectomy, history of bilateral oophorectomy, use of Norplant or Depo-Provera for contraception. History of bleeding diathesis |
结果
主要结果指标
1. Diabetes and Heart Disease Risk [By Subject]
