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Diet and Health in Adults With Metabolic Syndrome

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状态招聘中
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University of Arkansas, Fayetteville

关键词

抽象

The prevalence of US adults with Metabolic Syndrome (MetS) is over 34%, impacting nearly 35% of all adults and 50% of those aged 60 years or older. MetS is characterized as a combination of underlying risk factors that when, occurring together, increase the risk for chronic diseases such as type 2 diabetes mellitus (T2DM), cardiovascular disease, stroke, and certain types of cancer, resulting in an 1.6-fold increase in mortality. According the American Heart Association, health risks associated with Metabolic Syndrome can be significantly reduced by reducing body weight and eating a diet that is rich in whole grains, fruits, and vegetables. Potatoes (e.g. skin-on white potatoes) are an excellent source of potassium, vitamin C, and vitamin B6 and a good source of magnesium and dietary fiber. In addition, the potato has greater dry matter and protein per unit growing area compared with cereals. Despite this, consumers tend to believe that potatoes are high in calories and in fat compared with other carbohydrate sources such as rice or pasta, an incorrect assumption since a potato has negligible fat and a low energy density similar to legumes. Data from short-term nutrition intervention trials, suggest that potatoes consumed as part of a low-glycemic load meal can play a role in the prevention or treatment of MetS. However, the impact of long-term potato consumption on cardiometabolic risk factors associated with MetS is not known. Therefore, there is a critical need to determine if regular (> 4 times per week) potato consumption can improve cardiometabolic health in individuals with MetS.

日期

最后验证: 12/31/2019
首次提交: 04/25/2019
提交的预估入学人数: 04/29/2019
首次发布: 05/01/2019
上次提交的更新: 01/24/2020
最近更新发布: 01/27/2020
实际学习开始日期: 05/31/2019
预计主要完成日期: 12/30/2020
预计完成日期: 05/29/2021

状况或疾病

Metabolic Syndrome

干预/治疗

Dietary Supplement: Higher protein, low glycemic load diet

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手臂组

干预/治疗
Experimental: Higher Protein, Low Glycemic Load with Potatoes
Higher Protein, Low Glycemic Load with Potatoes (HPLG-P): low- to moderate- glycemic load meals containing white potatoes. Participants will consume low- to moderate-glycemic meals for 16 weeks and will need to consume at least 4 meals containing white potatoes.
Active Comparator: Higher Protein, Low Glycemic Load with Processed Potatoes
Higher Protein, Low Glycemic Load with Processed Potatoes (HPLG-PP): low- to moderate- glycemic load meals containing processed white potato products. Participants will consume low- to moderate-glycemic meals for 16 weeks and will need to consume at least 4 meals containing white potatoes.
Placebo Comparator: Higher Protein, Low Glycemic Load - Control
Higher Protein, Low Glycemic Load (HPLG-C): low- to moderate- glycemic load meals containing control carbohydrate (e.g. rice, pasta). Participants will consume low- to moderate-glycemic meals for 16 weeks and will need to consume at least 4 meals containing control carbohydrate sources.

资格标准

有资格学习的年龄 18 Years 至 18 Years
有资格学习的性别All
接受健康志愿者
标准

Inclusion Criteria:

- Resides in Northwest Arkansas

- Age 18+ years

- Metabolic Syndrome (characterized by participant having three or more of the following measurements: abdominal obesity, triglyceride level over 150 mg/dl, HDL cholesterol < 40 mg/dl in men and 50 mg/dl in women, systolic blood pressure of 130 mm Hg or diastolic blood pressure of 85 mm Hg, and/or fasting glucose > 100 mg/dL)

- All ethnicities

- Female and male

- Currently consuming a high glycemic load diet

Exclusion Criteria:

- Food allergies

- Dietary restrictions (e.g. vegetarian, vegan, etc.)

- Trying to lose weight in last 3 months

- Prescription medications related to heart disease or type 2 diabetes

- Fear of needles

结果

主要结果指标

1. Serum lipid levels [Change from baseline at 16 weeks]

Total Cholesterol, LDL-Cholesterol, HDL-Cholesterol, Free Fatty Acids, Triglycerides

2. Plasma glucose levels [Change from baseline at 16 weeks]

Plasma glucose levels

次要成果指标

1. Waist circumference [Change from baseline at 16 weeks]

Waist circumference in centimeters

2. Dietary intake [Change of time of study (16 weeks)]

Monthly food records will be recorded to determine changes in diet intake

3. Mood [Change from baseline at 16 weeks]

Mood will be measured using the Profile of Mood States questionnaire

4. Sleep quality and duration [Change from baseline at 16 weeks]

Sleep quality will be assessed using the Pittsburgh Sleep Quality Index

5. Sleep duration [Change from baseline at 16 weeks]

Sleep duration will be assessed using an Actigraph sleep monitor

6. Marker of appetite and sleep [Change from baseline at 16 weeks]

Orexin (also known as hypocretin)

7. Appetite [Change from baseline at 16 weeks]

Anorexigenic appetite hormone - PYY (peptide tyrosine tyrosine)

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