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Dietary Intakes and Periodontal Health: A Follow-Up Study

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赞助商
Brock University
合作者
Dr. Peter C. Fritz, Periodontal Wellness & Implant Surgery

关键词

抽象

A previous study, on which this study is based, found that a diet higher in fruits and vegetables, beta-carotene, vitamin C, alpha-tocopherol, and fish oils (specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) was positively associated with periodontal healing after sanative therapy (NCT02291835). The investigator's next step, in the present study, is to determine long-term benefits of sanative therapy in which patients have regular maintenance hygiene cleanings on periodontal health. Specifically, the relationship between intakes of specific foods, nutrients and supplements with clinical periodontal outcomes will be studied.

描述

Periodontitis is a chronic oral infection that results in the breakdown of connective tissue and alveolar bone that support the teeth. Bacteria and the body's own immune system mediate the severity of periodontitis, where teeth may become loose, fall out or have to be removed. Sanative therapy is a non-surgical process involving mechanical debridement of bacterial biofilms on roots of teeth, below the gum line. Participants in this present study previously underwent sanative therapy several years ago and have been attending the clinic for regular maintenance appointments to maintain periodontal health. While significant associations were observed with higher intakes of fruits and vegetables and specific nutrients (vitamins C and E, beta-carotene, fish oils) within a few months after sanative therapy, this study will follow-up these findings to determine if such relationships persist during a period of relatively stable periodontal health. Given new insights into a potential role of flavonoids in maintaining periodontal health, this aspect will also be studied. The overall objective is to determine if higher intakes of foods, nutrients and supplements known to have osteogenic and immunomodulatory effects are associated with improved clinical outcomes in individuals who previously underwent sanative therapy. At the regular maintenance appointment, clinical measures will be evaluated (clinical attachment loss, probing depth, bleeding on probing, plaque index). As well, the following will be evaluated: dietary intakes of macronutrients and micronutrients using the Block 2015 food frequency questionnaire; intakes of fruit, vegetables and fiber using the Block Dietary Fruit-Vegetable-Fiber Screener; nutritional supplement use and tea intake using specially developed questionnaires and salivary markers of inflammation using biochemical assays.

日期

最后验证: 04/30/2018
首次提交: 03/02/2017
提交的预估入学人数: 03/02/2017
首次发布: 03/07/2017
上次提交的更新: 05/08/2018
最近更新发布: 05/10/2018
实际学习开始日期: 12/31/2016
预计主要完成日期: 03/31/2018
预计完成日期: 04/30/2018

状况或疾病

Periodontal Attachment Loss
Periodontal Pocket

-

资格标准

有资格学习的年龄 19 Years 至 19 Years
有资格学习的性别All
取样方式Probability Sample
接受健康志愿者
标准

Inclusion Criteria:

- previously participated in the original study (NCT02291835)

Exclusion Criteria:

- under 19 years of age

- have not participated in the previous study as this study is a direct follow-up of those participants

结果

主要结果指标

1. Clinical Attachment Loss (CAL) (also called Periodontal Attachment Loss) [At maintenance appointment (1 hour)]

Clinical Attachment Loss is a routine clinical measure of periodontal health (measured in mm)

次要成果指标

1. Probing Depth [At maintenance appointment (1 hour)]

Probing depth is a routine clinical measure of periodontal health (measured in mm)

2. Bleeding on Probing [At maintenance appointment (1 hour)]

Bleeding on Probing is a measure of inflammation and determined as the percent of bleeding sites that are measured at 6 sites per tooth.

3. Plaque Index [At maintenance appointment (1 hour)]

O'Leary Plaque Score Index is a score of the total amount of plaque present at 4 surfaces of the tooth.

其他成果措施

1. Dietary Nutrient Intakes [At maintenance appointment (1 hour)]

Dietary intakes measured using the Block food frequency questionnaire

2. Tea Intakes [At maintenance appointment (1 hour)]

Quantity and type of tea consumed will be determined using a questionnaire

3. Servings of Fruits, Vegetables and Fiber [At maintenance appointment (1 hour)]

A questionnaire called the Block Fruit-Vegtable-Fiber Screener is used to provide a score that pertains to number of servings of fruits, vegetables and fiber consumed over past month

4. Dietary Supplement Intakes [At maintenance appointment (1 hour)]

Intakes of specific dietary supplements measured using a dietary supplement questionnaire

5. Salivary Markers of Inflammation [At maintenance appointment (1 hour)]

Specific markers of inflammation measured in saliva

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