Dietary Polyphenols and Insulin Sensitivity in Overweight and Obese Humans
关键词
抽象
日期
| 最后验证: | 08/31/2018 |
| 首次提交: | 08/19/2013 |
| 提交的预估入学人数: | 03/01/2015 |
| 首次发布: | 03/05/2015 |
| 上次提交的更新: | 09/02/2018 |
| 最近更新发布: | 09/04/2018 |
| 实际学习开始日期: | 07/31/2012 |
| 预计主要完成日期: | 04/30/2014 |
| 预计完成日期: | 08/31/2014 |
状况或疾病
干预/治疗
Dietary Supplement: EGCG+RSV-supplementation
Dietary Supplement: Placebo
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Placebo Comparator: Placebo micro-cellulose-filled Placebo | Dietary Supplement: Placebo |
| Active Comparator: EGCG+RSV-supplementation EGCG+RSV: 300mg/d + 80mg/d | Dietary Supplement: EGCG+RSV-supplementation Teavigo (~300mg/d) Resveratrol (~80mg/d) |
资格标准
| 有资格学习的年龄 | 20 Years 至 20 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Overweight men and women (BMI≥25kg/m2-39.9kg/m2), - Aged 20-35 and 35-50 years - Caucasian - Normal fasting glucose (< 6.1 mmol/L) and normal postprandial glucose (2h-glucose <7.8 mm) - Normal blood pressure (systolic blood pressure 100-140 mmHg, diastolic blood pressure 60-90 mmHg) - Weight stable in last 3 months (± 2kg) Exclusion Criteria: - Women lactating, pregnant or (post) menopausal - Regular smokers - People with intensive fitness training, eg. athletes (≥ 3 per week ≥ 1 hour training) - Habitual consumption of green tea (more than 1 cup per day) or products containing green tea extract - Total caffeine consumption > 300 mg/day (1 can of cola or 2 cups of regular coffee or 2 cups of black tea or 1 cup of coffee and 1 cup of black tea or other combinations) - Alcohol intake >20 g/day (2 glasses of beer or wine) - Any dietary vitamins or dietary supplements - Diabetes mellitus (defined as FPG ≥ 7.0 mmol/l and/or 2hPG ≥ 11.1 mmol/l) - Serious pulmonary, cardiovascular, hepatic or renal disease - History of cardiovascular disease - All other relevant medical disorders that potentially interfere with this trial (e.g. history of gastro-intestinal, liver or thyroid disorders) - Current use of medication interfering with study intervention or interfering with study endpoints/hypotheses (e.g. medication containing caffeine like analgesics, anorectics and analeptics) - Not to be able to understand the study information - Subjects on a special diet or vegetarian - Blood donation 2 months prior to the study and during the study - Participation in other studies - Drug use - Coagulation disorders (i.e. hemophilia (type A, B and C), von Willebrand disease, vitamin K deficiency, afibrinogenemia, disseminated intravascular coagulation and thrombosis) - Use of anti-coagulant medication - Acute or history of gastrointestinal diseases (Morbus Crohn, Colitis Ulcerosa) - Intake of Antibiotics for the last 3 months |
结果
主要结果指标
1. Systemic insulin sensitivity [change from week 0 to week 12 after supplementation]
次要成果指标
1. skeletal muscle mitochondrial function [change from week 0 to week 12 after supplementation]
其他成果措施
1. lipid oxidation [change from week 0 to week 12 after supplementation]
2. skeletal muscle and adipose tissue lipolysis [change from week 0 to week 12 after supplementation]
