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Does Antidepressant Use Blunt Adaptations to Exercise?

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California State University, San Marcos

关键词

抽象

Nearly one out of ten US adults over the age of 18 currently takes antidepressant medication, which can also treat other conditions such as anxiety. Combining pharmaceutical treatment with exercise may yield even greater benefits than using drugs alone, and this is commonly prescribed for depression. However, little is known about the drug-exercise interactions and their influence on metabolic health. A common side effect of antidepressant use is weight gain, particularly abdominal (visceral) fat, which is highly detrimental to overall health. Exercise is a well-known counter to abdominal fat accumulation. The aim of the proposed study is to compare the efficacy of 6 weeks of exercise training to reduce abdominal fat in healthy overweight/obese adults either taking or not taking antidepressant medication. Twenty-four inactive overweight/obese, but otherwise healthy, adults will complete 6 weeks of an exercise training intervention consisting of three days of aerobic exercise training per week. Participants will either not be taking antidepressant medication or will have been on their medication for at least 1 year. The primary outcome will be abdominal fat determined by waist circumference and dual x-ray absorptiometry, which is considered one of the optimal methods for assessment of abdominal fat.

日期

最后验证: 06/30/2019
首次提交: 04/25/2019
提交的预估入学人数: 04/28/2019
首次发布: 05/01/2019
上次提交的更新: 07/21/2019
最近更新发布: 07/22/2019
实际学习开始日期: 06/14/2019
预计主要完成日期: 06/30/2020
预计完成日期: 06/30/2020

状况或疾病

Depression
Depressive Disorder
Metabolic Syndrome

干预/治疗

Behavioral: Exercise

-

手臂组

干预/治疗
Active Comparator: Control
This arm will consist of healthy overweight and obese individuals who are physically inactive and do not have clinically diagnosed depression or depression symptoms.
Experimental: Antidpressants
This arm will consist of healthy overweight and obese adults who are physically inactive and who are diagnosed with clinical depression and have been taking antidepressant medications for at least 1 year.

资格标准

有资格学习的年龄 18 Years 至 18 Years
有资格学习的性别All
接受健康志愿者
标准

Inclusion Criteria:

- Participants will be English language speakers

- Male or females between the ages of 18-40.

- All genders and ethnicities.

- Healthy as assessed by a health history questionnaire (no diagnosed physical diseases or conditions preventing participation in exercise).

- Individuals on antidepressants will be recruited if they are consuming selective serotonin reuptake inhibitors (SSRIs) and selective serotonin and norepinephrine reuptake inhibitors (SNRIs) only. Participants will send prescription information after consent has been provided as part of the screening process, including the dose and frequency of medication.

- A body mass index (BMI) of 25 or greater is required for inclusion.

Exclusion Criteria:

- Inability to complete moderate-vigorous exercise.

- Taking first generation antidepressant medications or other medications such as monoamine oxidase inhibitors (MAOI).

- Other medications, such as medications for attention-deficit hyper-activity disorder or metabolism

- Undiagnosed depression that may be unveiled during the screening process.

结果

主要结果指标

1. Visceral adipose tissue (VAT) [Change from baseline after 6 weeks.]

VAT assessed by dual-energy X-ray absorptiometry (DXA)

2. Waist circumference [Change from baseline after 6 weeks.]

Waist circumference is a proxy of VAT

次要成果指标

1. Aerobic fitness [Change from baseline after 6 weeks.]

Fitness assessed via a maximal treadmill exercise test

2. Blood pressure [Change from baseline after 6 weeks.]

Resting blood pressure assessed with an oscillatory blood pressure monitor

3. Blood glucose [Change from baseline after 6 weeks.]

Fasting capillary glucose sample

4. Blood lipid panel [Change from baseline after 6 weeks.]

Fasting capillary blood sample for triglycerides and cholesterol

5. Body mass [Change from baseline after 6 weeks.]

Body mass measured on a scale

6. Fat mass [Change from baseline after 6 weeks.]

Total and segmental body fat mass measured by DXA

7. Lean mass [Change from baseline after 6 weeks.]

Total and segmental lean mass measured by DXA

8. Dietary intake [Change from baseline after 6 weeks.]

Food logs recorded over two week days and one weekend day

9. Physical activity [Change from baseline after 6 weeks.]

Free-living physical activity assessed over 7 days via combined heart-rate and accelerometry

10. Depression symptoms [Change from baseline after 6 weeks.]

Symptoms of depression assessed with Beck's Depression Inventory (BDI). The BDI is a 21-item questionnaire that measures total depressive symptoms. Individual item scores range from 0-3. Individual items are then summed to provide a total score, ranging from 0 to 63.

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