Does Antidepressant Use Blunt Adaptations to Exercise?
关键词
抽象
日期
最后验证: | 06/30/2019 |
首次提交: | 04/25/2019 |
提交的预估入学人数: | 04/28/2019 |
首次发布: | 05/01/2019 |
上次提交的更新: | 07/21/2019 |
最近更新发布: | 07/22/2019 |
实际学习开始日期: | 06/14/2019 |
预计主要完成日期: | 06/30/2020 |
预计完成日期: | 06/30/2020 |
状况或疾病
干预/治疗
Behavioral: Exercise
相
手臂组
臂 | 干预/治疗 |
---|---|
Active Comparator: Control This arm will consist of healthy overweight and obese individuals who are physically inactive and do not have clinically diagnosed depression or depression symptoms. | |
Experimental: Antidpressants This arm will consist of healthy overweight and obese adults who are physically inactive and who are diagnosed with clinical depression and have been taking antidepressant medications for at least 1 year. |
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Participants will be English language speakers - Male or females between the ages of 18-40. - All genders and ethnicities. - Healthy as assessed by a health history questionnaire (no diagnosed physical diseases or conditions preventing participation in exercise). - Individuals on antidepressants will be recruited if they are consuming selective serotonin reuptake inhibitors (SSRIs) and selective serotonin and norepinephrine reuptake inhibitors (SNRIs) only. Participants will send prescription information after consent has been provided as part of the screening process, including the dose and frequency of medication. - A body mass index (BMI) of 25 or greater is required for inclusion. Exclusion Criteria: - Inability to complete moderate-vigorous exercise. - Taking first generation antidepressant medications or other medications such as monoamine oxidase inhibitors (MAOI). - Other medications, such as medications for attention-deficit hyper-activity disorder or metabolism - Undiagnosed depression that may be unveiled during the screening process. |
结果
主要结果指标
1. Visceral adipose tissue (VAT) [Change from baseline after 6 weeks.]
2. Waist circumference [Change from baseline after 6 weeks.]
次要成果指标
1. Aerobic fitness [Change from baseline after 6 weeks.]
2. Blood pressure [Change from baseline after 6 weeks.]
3. Blood glucose [Change from baseline after 6 weeks.]
4. Blood lipid panel [Change from baseline after 6 weeks.]
5. Body mass [Change from baseline after 6 weeks.]
6. Fat mass [Change from baseline after 6 weeks.]
7. Lean mass [Change from baseline after 6 weeks.]
8. Dietary intake [Change from baseline after 6 weeks.]
9. Physical activity [Change from baseline after 6 weeks.]
10. Depression symptoms [Change from baseline after 6 weeks.]