Does Medical Cannabis Reduce Opioid Use in Adults With Pain
关键词
抽象
描述
This study will examine how medical cannabis use affects opioid analgesic use, with particular attention to THC/CBD content and adverse events. We will enroll adults with (a) severe or chronic neuropathic or joint pain, (b) prescribed opioid analgesic use, (c) new certification for medical cannabis, and (d) newly dispensed soft gel capsule products from Vireo (medical cannabis dispensary) (including a high THC:low CBD product, an equal THC:CBD product, and a low THC:high CBD product). Over the 14 weeks, data sources will include questionnaires; medical, pharmacy, and Prescription Monitoring Program (PMP) records; and urine samples. The primary independent variable will be type of soft gel capsule product, and the primary outcome will be cumulative opioid analgesic dose.
日期
| 最后验证: | 06/30/2020 |
| 首次提交: | 03/11/2020 |
| 提交的预估入学人数: | 03/11/2020 |
| 首次发布: | 03/12/2020 |
| 上次提交的更新: | 07/15/2020 |
| 最近更新发布: | 07/16/2020 |
| 实际学习开始日期: | 07/30/2020 |
| 预计主要完成日期: | 12/30/2022 |
| 预计完成日期: | 12/30/2022 |
状况或疾病
相
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 取样方式 | Non-Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - At least 18 years of age - English or Spanish fluency - New certification for medical cannabis within 90 days - No medical cannabis dispensed or used within the previous 6 months - New soft-gel capsule product dispensed at Vireo - Medical cannabis qualifying conditions or complications of "chronic or severe pain" or "pain that degrades health and functional capability as an alternative to opioid use or substance use disorder" - Joint or neuropathic pain - Current severe pain - Dispensed opioid analgesics within the last 30 days - Self-reported use of opioid analgesics Exclusion Criteria: - Inability to provide informed consent - Inability to complete study visits over 14 weeks - Qualifying conditions for medical cannabis in NY that are likely to cause unique pain syndromes - Terminal illness - Current or prior psychotic disorder - Current or prior buprenorphine or methadone treatment for opioid use disorder - Allergies to tapioca or coconut |
结果
主要结果指标
1. Opioid analgesic use [Opioid analgesic use will be weekly cumulative dose of opioid analgesics over 14 weeks.]
次要成果指标
1. Adverse events [Adverse events will be over 14 weeks]
