Effect of Antidepressants on White Matter Structure
关键词
抽象
描述
40 subjects will be included in the study. Diagnosis will be confirmed by MINI. Participants will be characterised using questionnaires, pain threshold, cognition, facial expression recording and MRI. Desvenlafaxine will be initiated at 50mg AM. At week 8 Desvenlafaxine may be increased to 100mg as clinically indicated. Measures will be repeated at the end of the study.
日期
| 最后验证: | 11/30/2011 |
| 首次提交: | 12/11/2011 |
| 提交的预估入学人数: | 12/13/2011 |
| 首次发布: | 12/14/2011 |
| 上次提交的更新: | 12/13/2011 |
| 最近更新发布: | 12/14/2011 |
| 实际学习开始日期: | 10/31/2011 |
| 预计主要完成日期: | 08/31/2013 |
| 预计完成日期: | 10/31/2013 |
状况或疾病
干预/治疗
Drug: Desvenlafaxine
相
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Major depression - Age 18 to 55 - Hamilton grater or equal to 20 Exclusion Criteria: - Major neurologic disorder - Major cardiovascular disorder - Unstable medical condition - Significant psychiatric co-morbidity - Current substance dependance - Pregnancy or lactation -Treatment resistance as defined by nonresponse to 2 or more antidepressant treatments (adequate dose and duration) - |
结果
主要结果指标
1. Anisotropy [16 weeks]
次要成果指标
1. cognitive measures [16 weeks]
2. Pain threshold [16 weeks]
