Effect of Glutathione on Blood Alcohol and Hangover Symptoms

Type of Study: Double-blinded control

Population: 100 males

Inclusion Criteria:

- Males 20-40 years

- Healthy, without chronic diseases, especially must have normal hepatic function, measured by serum SGPT

- No history of alcoholic allergy

- Drink alcohol regularly, at least once a week

- Agree to be a subject by standard consent form

Exclusion Criteria:

- Subject wants to end the study

- Some impending danger to subjects

Number of subjects : 100

Methodology

1. Subjects are recruited;

2. History taking, physical examination and SGPT are done by M.D.;

3. 100 subjects are distributed randomly to numbers 1-100;

4. Factory provides 2 groups of capsules in randomized packets numbered 1 -100; each package contains 3 sub-packages; each sub-package contains 2 capsules of either placebo or 370 mg glutathione capsules. All the three sub-packages will be all placebo or all glutathione. 50 packages are placebo and 50 packages are glutathione;

5. Subjects are examined as follows:

- Hour 0: 3 ml of blood taken for blood alcohol and blood acetaldehyde;

- Hour 0- 1: consume Thai Whisky (40% alcohol) 60 ml with snacks;

- Hour 1: ml of blood taken for blood alcohol and blood acetaldehyde;

- Hour 1.30: ml of blood taken for blood alcohol and blood acetaldehyde;

- Hour 2.30: ml of blood taken for blood alcohol and blood acetaldehyde;

- Hour 3.30: ml of blood taken for blood alcohol and blood acetaldehyde;

- Hour 12: ml of blood taken for blood alcohol and blood acetaldehyde, and Alcohol Hangover Symptom evaluation of each subject is done individually.

Using Wendy S. Slutske et al Scale 0-4:

0= no symptom

1. minimal

2. some

3. much

4. most

Symptoms are

1. extreme thirst or dehydration

2. more tired than usual

3. headache

4. nausea

5. vomiting

6. very weak

7. difficulty concentrating

8. more sensitive to light and sound than usual

9. more sweating than usual

10. have a lot of trouble sleeping

11. anxious

12. depressed

13. trembling or shaking

Blood alcohol, blood acetaldehyde and hangover symptoms are statistically evaluated for significance.