Effectiveness of Acupuncture for Depressed Patients Taking Antidepressant Medications
关键词
抽象
日期
| 最后验证: | 06/30/2012 |
| 首次提交: | 06/14/2012 |
| 提交的预估入学人数: | 07/01/2012 |
| 首次发布: | 07/05/2012 |
| 上次提交的更新: | 07/01/2012 |
| 最近更新发布: | 07/05/2012 |
| 实际学习开始日期: | 07/31/2007 |
| 预计主要完成日期: | 03/31/2010 |
| 预计完成日期: | 03/31/2010 |
状况或疾病
干预/治疗
Procedure: Acupuncture
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: Acupuncture All participants received open acupuncture augmentation treatment per the uniform acupuncture treatment protocol that we developed according to Traditional Chinese Medicine (TCM) principles for treating depression (see Intervention Description). | Procedure: Acupuncture Our acupuncture treatment protocol included: HT-7 and LI-4 on the hands bilaterally, and ST-36, SP-6, and LR-3 on the legs bilaterally, with gentle manual tonification every 10 minutes; and GV-20 and GV- 24.5 (Yintang), along the midline of the head. |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Ages 18-65 - A HAM-D-17 score of >= 14 - Partial or nonresponse to a standard antidepressant (monotherapy or combination) at an adequate dose over the past 8 or more weeks (natural agents such as omega-3 fatty acids, St John's wort, SAMe, and folic acid, were allowed as antidepressants) - Concurrent psychotherapy was allowed, provided that it was not initiated within the 3 months prior to study entry. Exclusion Criteria: - A primary diagnosis other than major depressive disorder, or any history of psychosis or mania - Conditions that could make it difficult to conclusively determine that depressive symptoms were the result of major depression and not some other condition, including any form of substance abuse or dependence within the last 6 months, other medical conditions that could be the basis of a depression (including epilepsy, history of an abnormal EEG, severe head trauma, or stroke) - Serious uncontrolled medical conditions (e.g. poorly controlled diabetes, severe congestive heart failure), or other medical conditions that had not been stable for at least 3 months - Having had electroconvulsive therapy (ECT) during the past year - Current active suicidal or self-injurious potential necessitating immediate treatment. |
结果
主要结果指标
1. Response to acupuncture augmentation treatment, defined as a change in scores on the Hamilton Depression Rating Scale, 17 items (HAM-D-17) from baseline to endpoint. [Baseline and all acupuncture sessions (weekly) for 8 weeks]
次要成果指标
1. Evidence of acupuncture augmentation's tolerability and acceptability, as determined clinically by the participant and study doctor. [Once per acupuncture session (weekly) for 8 weeks]
