Effects of Blueberry on Gut Microbiota and Metabolic Syndrome
关键词
抽象
日期
| 最后验证: | 04/30/2020 |
| 首次提交: | 07/05/2017 |
| 提交的预估入学人数: | 08/27/2017 |
| 首次发布: | 08/28/2017 |
| 上次提交的更新: | 05/03/2020 |
| 最近更新发布: | 05/04/2020 |
| 实际学习开始日期: | 08/31/2017 |
| 预计主要完成日期: | 01/13/2019 |
| 预计完成日期: | 11/30/2021 |
状况或疾病
干预/治疗
Dietary Supplement: Blueberry powder
Dietary Supplement: Blueberry placebo powder
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: Blueberry powder | Dietary Supplement: Blueberry powder Subjects will consume blueberry powder during 8 weeks to test the possible effects of blueberries on gut microbiota composition and on metabolic syndrome parameters. |
| Placebo Comparator: Blueberry placebo powder | Dietary Supplement: Blueberry placebo powder Subjects will consume blueberry placebo powder to test if there is a significant difference on the impact on gut microbiota composition and metabolic syndrome parameters between this treatment and the active treatment (blueberry powder). |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Men and premenopause women in good health - Caucasians - At least one of the following : BMI between 25 and 40 kg/m2 or Waist circumference ≥ 80 cm for women and ≥ 94 cm for men - At least one of the following : TG ≥ 1.35 mmol/L or fasting insulinemia ≥ 42 pmol/L Exclusion Criteria: - Metabolic disorders (hypertension, diabetes, hypercholesterolemia) - Regular use of medication affecting study parameters - Use of natural health product in the last 3 months - Use of antibiotics in the last 3 months - Nicotine users - Allergy or intolerance for blueberries - Blueberry taste aversion - More than 2 alcohol drinks par day - Particular dietary habits (vegetarism, gluten-free diet, cetogenic diet...) - Weight change of more than 5% in the last 3 months - Surgery in the last 3 months or planed during the study |
结果
主要结果指标
1. Changes in plasma insulin/glucose of overweight/obese men and women taking either blueberry powder or placebo blueberry powder [12 months]
2. Changes in plasma lipids/lipoproteins of overweight/obese men and women taking either blueberry powder or placebo blueberry powder [12 months]
次要成果指标
1. Changes in gene expression in overweight/obese men and women taking either blueberry powder or placebo blueberry powder [3-6 months]
2. Changes in metabolites concentration in overweight/obese men and women taking either blueberry powder or placebo blueberry powder [3-6 months]
3. Changes in the gut microbiota composition in overweight/obese men and women taking either blueberry powder or placebo blueberry powder [3-6 months]
4. Changes in blood pressure of overweight/obese men and women taking either blueberry powder or placebo blueberry powder [12 months]
5. Changes in intestinal integrity of overweight/obese men and women taking either blueberry powder or placebo blueberry powder [12 months]
6. Changes in inflammation biomarkers of overweight/obese men and women taking either blueberry powder or placebo blueberry powder [12 months]
