Effects of Cannabis on Prescription Drug Abuse Liability and Analgesia
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New York State Psychiatric Institute
临床试验: NCT03679949
BioSeek: nct03679949
关键词
抽象
The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-liability effects of a sub-threshold dose of a commonly used analgesic.
日期
| 最后验证: | 03/31/2020 |
| 首次提交: | 09/18/2018 |
| 提交的预估入学人数: | 09/19/2018 |
| 首次发布: | 09/20/2018 |
| 上次提交的更新: | 04/02/2020 |
| 最近更新发布: | 04/06/2020 |
| 实际学习开始日期: | 03/31/2019 |
| 预计主要完成日期: | 08/30/2021 |
| 预计完成日期: | 08/31/2022 |
状况或疾病
Pain
Abuse, Drug
干预/治疗
Drug: Oxycodone
Drug: Cannabis (THC:CBD = ~ 1:0)
Drug: Cannabis (THC:CBD = ~ 0:1)
Drug: Cannabis (THC:CBD = ~ 1:1)
Drug: Placebo
相
相 1
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Placebo Comparator: Placebo Participants will receive 0 mg oxycodone (oral) and placebo cannabis (vaporized) | |
| Experimental: Oxycodone Participants will receive 2.5 mg oxycodone (oral) and placebo cannabis (vaporized) | |
| Experimental: Cannabis (THC:CBD = ~1:0) Participants will receive 0 mg oxycodone (oral) and cannabis with high THC concentrations (vaporized) | |
| Experimental: Cannabis (THC:CBD = ~ 0:1) Participants will receive 0 mg oxycodone (oral) and cannabis with high CBD concentrations (vaporized) | |
| Experimental: Cannabis (THC:CBD = ~ 1:1) Participants will receive 0 mg oxycodone (oral) and cannabis with equal CBD and THC concentrations (vaporized) | |
| Experimental: Cannabis (THC:CBD = ~1:0) + Oxycodone Participants will receive 2.5 mg oxycodone (oral) and cannabis with high THC concentrations (vaporized) | |
| Experimental: Cannabis (THC:CBD = ~ 0:1) + Oxycodone Participants will receive 2.5 mg oxycodone (oral) and cannabis with high CBD concentrations (vaporized) | |
| Experimental: Cannabis (THC:CBD = ~ 1:1) + Oxycodone Participants will receive 2.5 mg oxycodone (oral) and cannabis with equal concentrations of THC and CBD (vaporized) |
资格标准
| 有资格学习的年龄 | 21 Years 至 21 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Male or non-pregnant female aged 21-53 years - Previous cannabis use - Previous opioid use - Urine test positive for recent cannabis use - Being able to perform all study procedures - Currently practicing an effective form of birth control (women only) Exclusion Criteria: - Meeting criteria for some Use Disorders - Report regular illicit drug use - If medical history, physical and psychiatric examination, or laboratory tests performed during the screening process revealed any significant illness |
结果
主要结果指标
1. Subjective Effects [6 weeks]
Participants will rate "drug liking", "good drug effects", and "high" on a visual analogue scale (VAS; 1-100mm).
2. Cold Pressor Test [6 weeks]
Participants will immerse their hand in a bucket of ice water to determine pain threshold and pain tolerance latencies (in seconds).
