Effects of Mild Hypobaric Hypoxia on Oxygen Saturation During Sleep
关键词
抽象
描述
This study has 6 primary objectives/hypotheses:
1. Replicate findings of earlier study in which no effects of altitude were observed on post sleep neurobehavioral performance, sleep quantity or quality.
2. Determine if sleep at 6000 feet has effects similar to sleep at 8000 feet.
3. Identify if central or obstructive apnea is responsible for the reduction in oxygen saturation observed during sleep at 8000 feet.
4. Determine if respiratory abnormalities observed at 6000 feet are similar but less severe than at 8000 feet.
5. Determine if there are individual differences in respiratory physiology at sea level that enable prediction of pronounced respiratory disturbances during sleep at altitude.
6. Determine if changes in autonomic nervous activity, measured by heart rate variability, occur, and if so, do they persist for 8 hours.
Twenty healthy males between 30 and 60 years of age whose baseline apnea-hypopnea index is less than 15/hour will be recruited from the general population surrounding Burnaby, British Columbia, Canada. Women are excluded because of the changes in sleep structure associated with the menstrual cycle.
Participants will be involved in the blinded crossover study for a 14 day period during which time they will monitor their sleep by actigraphy and sleep diaries, will spend 2 nights an altitude chamber at Simon Fraser University at ambient barometric pressure to become adapted to sleeping in that environment, then spend 3 study nights, each followed by 2 rest nights, sleeping at barometric pressures equivalent to sea level, 6000 feet, and 8000 feet. The order of exposures will be randomly balanced.
Pre study physiologic measures will include hypoxic ventilatory response, hypercapnic ventilatory response, and during one of the adaptation nights, apnea hypoxia index. Study sessions will consist of a 4 hour presleep period, a 6 hour sleep period, and a 1 hour post sleep period at the study barometric pressure. During the study sessions, heart rate, SpO2, polysomnographic measures, nasal air flow rates, and chest motion will be monitored and recorded. Psychomotor Vigilance Task response time will be measured before and after the sleep period. Heart rate will be recorded by ambulatory recording equipment for 8 hours following return to ambient barometric pressure conditions. This will be analyzed to determine if changes in heart rate variability are persistent.
Outcomes of primary interest will include total sleep time, duration of sleep stages, oxygen saturation, heart rate and heart rate variability, respiratory rates, air flow, and chest motion to assess if central or obstructive apnea is temporally related to reductions in oxygen saturation.
日期
最后验证: | 01/31/2010 |
首次提交: | 04/13/2008 |
提交的预估入学人数: | 04/14/2008 |
首次发布: | 04/15/2008 |
上次提交的更新: | 08/13/2012 |
最近更新发布: | 08/14/2012 |
实际学习开始日期: | 04/30/2008 |
预计主要完成日期: | 02/28/2009 |
预计完成日期: | 02/28/2009 |
状况或疾病
干预/治疗
Other: 2
Other: 1
Other: 3
相
手臂组
臂 | 干预/治疗 |
---|---|
Active Comparator: 1 Barometric pressure equivalent to sea level (760 mm Hg). | Other: 1 Sleep in barometric pressure equivalent to sea level. |
Experimental: 2 Barometric pressure equivalent to 6000 feet (609 mm Hg) | Other: 2 Sleep in reduced barometric pressure environment. |
Experimental: 3 Barometric pressure equivalent to 8000 feet (565 mm Hg). | Other: 3 Sleep in reduced barometric pressure environment. |
资格标准
有资格学习的年龄 | 30 Years 至 30 Years |
有资格学习的性别 | Male |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Male - Between 30 and 60 years of age. - Healthy, able to pass FAA Class III examination - Body mass index less than 30 - Height less than 75 inches - Ability to read and speak English Exclusion Criteria: - Prolonged residence above 5000 feet - Recent travel to altitudes above 5000 feet - Use of drugs or medications that affect sleep - History of mood or psychiatric disorders that affect sleep. - History of medical conditions that increase risk of adverse effects of hypoxia. - Apnea hypopnea index greater than 15/hr at ground level. |
结果
主要结果指标
1. SpO2 [Continuous during sleep]
2. Respiratory Disturbance [Continuous during sleep]
3. Sleep architecture [Continuous during sleep]
次要成果指标
1. Heart rate variability [Continuous during sleep and 8 hr following exposure]