Effects of Peanut Consumption on Postprandial Inflammation, Glucose and Triglycerides
关键词
抽象
描述
Previous research has demonstrated that a single meal high in saturated fatty acids (SFA) and glucose can induce increases in IL-6, TNF-α and CRP in abdominally obese and diabetic subjects. As over two-thirds of the U.S. population is overweight or obese, it is important to identify foods that can attenuate postprandial increases in lipids, glucose and inflammation in this population. Therefore, the purpose of the pilot study is to determine whether a high SFA / high glucose control meal will induce an acute inflammatory response in overweight individuals, and whether the addition of peanuts to this meal will ameliorate this response. To ensure that these effects are due to peanuts, and not to the increase in total fat, we will compare this response to another test meal that includes an oil blend with a similar fatty acid composition to peanuts.
日期
| 最后验证: | 04/30/2017 |
| 首次提交: | 04/12/2010 |
| 提交的预估入学人数: | 07/28/2010 |
| 首次发布: | 07/29/2010 |
| 上次提交的更新: | 05/25/2017 |
| 最近更新发布: | 05/30/2017 |
| 实际学习开始日期: | 07/31/2009 |
| 预计主要完成日期: | 12/31/2009 |
| 预计完成日期: | 01/31/2010 |
状况或疾病
干预/治疗
Dietary Supplement: Peanut
Dietary Supplement: Control
Dietary Supplement: Oil blend
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Placebo Comparator: Control Shake containing heavy whipping cream, glucose and chocolate syrup | Dietary Supplement: Control An oral liquid glucose (75g) and fat (high saturated fat from 60g heavy whipping cream) load. Chocolate syrup is added for flavor. |
| Experimental: Peanut Shake containing control (whipping cream, glucose and chocolate syrup) + 3oz of peanuts | Dietary Supplement: Peanut Shake containing 3.0oz of peanuts (including skin) + control (heavy whipping cream, glucose and chocolate syrup) |
| Experimental: Oil blend Shake containing control (heavy whipping cream, glucose and chocolate syrup) + oil blend (equivalent to fatty acids provided in 3oz peanuts) | Dietary Supplement: Oil blend Shake containing an oil blend (sunflower, sesame, olive and palm oils) + control (heavy whipping cream, glucose and chocolate syrup). The amount of oil added to the control will provide an equivalent amount of fat to that provided in 3 oz (85g) of peanuts |
资格标准
| 有资格学习的年龄 | 30 Years 至 30 Years |
| 有资格学习的性别 | Male |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - BMI >28 - LDL_C below 130 mg/dl - TG below 350 mg/dl - Blood pressure within normal ranges (below 140/90 mmHg) Exclusion Criteria: - Smoking - Allergies to peanuts or dairy products - Known intolerance for high fat meals - History of CVD, kidney disease, diabetes or inflammatory disease - Use of non-steroidal anti-inflammatories or immunosuppressants - Conditions requiring the use of steroids - Use of medication or supplements for elevated lipids, blood pressure or glucose |
结果
主要结果指标
1. Serum C-reactive protein [0min]
2. Serum C-reactive protein [60 min]
3. Serum C-reactive protein [120 min]
4. Serum C-reactive protein [240 min]
次要成果指标
1. Serum Glucose [0 min]
2. Serum Insulin [0 min]
3. Serum Triglycerides [0 min]
4. Serum Glucose [60 min]
5. Serum Glucose [120 min]
6. Serum Glucose [240 min]
7. Serum Insulin [60 min]
8. Serum Insulin [120 min]
9. Serum Insulin [240 min]
10. Serum Triglycerides [60 min]
11. Serum Triglycerides [120 min]
12. Serum Triglycerides [240 min]
