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Etiology of Diarrhea in Guinea-Bissau and in Finland

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状态
赞助商
Bandim Health Project
合作者
University of Helsinki
Stockholm University

关键词

抽象

Diarrhoea is the leading cause of death in the world with 2.2 million deaths every year. The majority of deaths are among children in developing countries, but the travellers encounter the disease as well. The studies on the aetiology have suffered from serious methodological deficiencies and the results are even controversial. At the same time, the current diagnostic methods are inadequate. The investigators have recently developed novel multiplex RT-PCR methods to cover the majority of diarrhoeal pathogens. The present study is a collaboration between Finland and Sweden/Guinea-Bissau. The aim is to characterize the causative agents of diarrhoea (a) in Finnish volunteers before and after a travel to tropical areas and, (b) in inhabitants of endemic areas in Guinea-Bissau. For these purposes stool samples will be collected from volunteers of different age groups and from healthy volunteers as well as those with diarrhea both in Guinea-Bissau and in Finland. In addition to pathogens, other intestinal microbes and antimicrobial resistance will be investigated

日期

最后验证: 02/28/2014
首次提交: 11/12/2010
提交的预估入学人数: 01/02/2011
首次发布: 01/03/2011
上次提交的更新: 03/09/2014
最近更新发布: 03/10/2014
实际学习开始日期: 10/31/2010
预计主要完成日期: 04/30/2013
预计完成日期: 11/30/2014

状况或疾病

Diarrhea

-

手臂组

干预/治疗
Children with diarrhea in Bissau
Children without diarrhea in Bissau
Children without diarrhea in Finland
Children with diarrhea in Finland
Adults without diarrhea in Finland
Adults with diarrhea in Finland
Adults without diarrhea in Bissau
Adults with diarrhea in Bissau

资格标准

有资格学习的性别All
取样方式Probability Sample
接受健康志愿者
标准

Inclusion Criteria:

1. Accepting to participate and willing to deliver 2 stool samples.

2. With diarrhea: the first 10 children and 10 adults presenting each month at the health facility Without diarrhea: In Bissau matched controls drawn from the registration system at Bandim Health Project. In Finland controls selected at the health facilities participating.

Exclusion Criteria:

- Not willing or able to deliver the stool samples

结果

主要结果指标

1. Type of pathogens in stool samples in percentage of included patients [2 years]

The percentage of included patients with different pathogens will be described.

次要成果指标

1. Type of microbes other than than pathogens in stool samples in percentage of included patients [2 years]

2. The patern of resistance to antimicrobials in isolated pathogens [2 years]

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