Exploration of the Lipid Metabolism During the Diabetic Pregnancies
关键词
抽象
描述
Plan of study:
Longitudinal study on 3 groups: 70 type 1 diabetic women, 70 type 2 diabetic women and 70 women with normal glucose tolerance during pregnancy. Recruitment in the department of Diabetology and Obstetrics of CHRU of Amiens and Lille.
Nutritional survey and sampling of blood in the 1st, 2nd and 3rd trimester of pregnancy and at 6 weeks post partum.
Collection of cord blood and placental tissues. Histological and molecular analysis of placenta will be realized both in the departments of Anatomopathology of Lille and Amiens and in Biochemistry Molecular Biology of CHRU of Lille.
Homocysteine and folate assays on cord blood will be centralized in Paris (Hospital St Louis).
Main criteria of judgment
Fetal weight corrected by the gestational age.
Expected results:
- An inverse correlation between maternal and fetal blood fatty acids ratios (polyunsaturated fatty acids/ monounsaturated fatty acids + saturated) and birth weight in the diabetic groups.
- Differences of distribution of fatty acids of maternal and foetal erythrocytic phospholipids correlated with the fetal weight.
- Qualitative and quantitative variations of expression of placental genes such as lipases and genes submitted to parental imprinting.
The biologic parameters will be confronted with the data of the nutritional survey and with glycemic control during pregnancy.
日期
| 最后验证: | 04/30/2016 |
| 首次提交: | 03/13/2008 |
| 提交的预估入学人数: | 03/18/2008 |
| 首次发布: | 03/19/2008 |
| 上次提交的更新: | 05/30/2016 |
| 最近更新发布: | 05/31/2016 |
| 实际学习开始日期: | 12/31/2007 |
| 预计主要完成日期: | 12/31/2011 |
| 预计完成日期: | 11/30/2013 |
状况或疾病
干预/治疗
Other: blood tests
Other: diet questionnaire
Other: umbilical cord blood collect
Other: placenta collect
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Other: type 1 diabetic pregnant women type 1 diabetic pregnant women | |
| Other: type 2 diabetic pregnant women type 2 diabetic pregnant women | |
| Other: healthy pregnant women healthy pregnant women with normal glucose tolerance |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | Female |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - pregnant women included before 16 amenorrhea weeks Exclusion Criteria: - obesity (BMI > 40kg/m2) - subject became pregnant with medical infertility treatment - tobacco > 10 - suspected abuse of alcohol |
结果
主要结果指标
1. fetal weight corrected by gestational age [just after delivery]
次要成果指标
1. cholesterol (total, HDL, LDL) [3 measures during pregnancy and 1 at post partum, 1 measure at time of delivery from fetal cord]
2. triglycerides [3 measures during pregnancy and 1 at post partum, 1 measure at time of delivery from fetal cord]
3. Apolipoprotein A/B rate [3 measures during pregnancy and 1 at post partum, 1 measure at time of delivery from fetal cord]
4. erythrocytary and plasmatic fatty acid distribution [3 measures during pregnancy and 1 at post partum, 1 measure at time of delivery from fetal cord]
