French West Indies Leptospirosis Study
关键词
抽象
描述
Principal objective
To determine if leptospiral bacterial load is associated with severe evolution of the disease (organ failure, internal bleeding, death) in French West Indies.
Secondary objective
1. To identify demographic, clinical, biological, bacteriological, and genetic factors (HLA) associated with severe complications of leptospirosis (organ failure, internal bleeding, death).
2. To identify demographic, clinical, biological, bacteriological, and genetic factors (HLA) associated with an altered quality of life after the acute phase of leptospirosis.
3. To collect human biological samples to allow studies of the individual susceptibility to the infection (genetic polymorphisms, HLA).
日期
最后验证: | 02/28/2018 |
首次提交: | 05/23/2012 |
提交的预估入学人数: | 05/24/2012 |
首次发布: | 05/27/2012 |
上次提交的更新: | 03/18/2018 |
最近更新发布: | 03/19/2018 |
实际学习开始日期: | 11/30/2010 |
预计主要完成日期: | 08/31/2012 |
预计完成日期: | 07/31/2018 |
状况或疾病
相
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | All |
取样方式 | Non-Probability Sample |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Adults (more than 18 years) - Consulting a participating hospital center (emergency room, full hospitalization, day hospitalization, or outpatient visit). - Diagnosis of leptospirosis confirmed by qPCR - Possibility of follow-up throughout the 12-week study period. - Patient registered in the French medical social security national program - Acceptance to participate in the study and in follow-up; informed consent of the patient or a legal representative (patients unable to sign the consent form). Exclusion Criteria: - Negativity of leptospirosis qPCR based diagnosis - Children under 18 years old - No possible follow-up after the first visit - Refusal to participate in the study - Patient not registered in the French medical social security national program |
结果
主要结果指标
1. Complicated forms of leptospirosis [12 weeks]
次要成果指标
1. quality of life [12 weeks]