Frequent Activity Snacks Breaks
关键词
抽象
日期
最后验证: | 07/31/2019 |
首次提交: | 03/02/2017 |
提交的预估入学人数: | 03/12/2017 |
首次发布: | 03/19/2017 |
上次提交的更新: | 08/11/2019 |
最近更新发布: | 08/12/2019 |
实际学习开始日期: | 01/31/2017 |
预计主要完成日期: | 07/30/2019 |
预计完成日期: | 12/30/2020 |
状况或疾病
干预/治疗
Behavioral: No intervention
Behavioral: Exercise intervention
Procedure: muscle and fat biopsy
Device: Continuous glucose monitoring
Device: Activity monitoring (ActivePal)
相
手臂组
臂 | 干预/治疗 |
---|---|
Active Comparator: No intervention Normal lifestyle. Subjects will undergo a muscle and fat biopsy at the start of the 4 w period and after. An oral glucose test at the start and after completion of the 4 week period. Physical activity and glucose will be monitored during the study period. | Behavioral: No intervention Normal lifestyle |
Experimental: Exercise intervention Followed by a 1 week normal run in period subjects will undergo a 3 min bout, every half hour between 8 am and 6 pm comprises of simple low-intensity exercise such as moderate walking about or climbing a flight of stairs over a 3-week period. Subjects will undergo a muscle and fat biopsy at the start of the 4 w period and after. An oral glucose test at the start and after completion of the 4 week period. Physical activity and glucose will be monitored during the study period. | Behavioral: Exercise intervention Mild exercise 3 min every half hour |
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Sedentary lifestyle, - BMI 30-40 kg/m2 Exclusion Criteria: - Unable to read Swedish (for informed consent), - anticoagulant therapy, - unability to perform intervention |
结果
主要结果指标
1. Change in metabolic health including insulin resistance [Change from baseline and 4 week intervention]
次要成果指标
1. Changes at the molecular level in skeletal and fat muscle biopsies [Change from baseline and 4 week intervention]
2. Changes at the molecular level in skeletal and fat muscle biopsies [Change from baseline and 4 week intervention]
3. Changes at the molecular level in skeletal and fat muscle biopsies [Change from baseline and 4 week intervention]
4. Changes in gene expression [Change from baseline and 4 week intervention]
5. Changes in physical activity [Change from baseline and 4 week intervention]
6. Changes in plasma glucose [Change from baseline and 4 week intervention]