Genetic Epidemiology and Energy Metabolism in Black Girls
关键词
抽象
描述
BACKGROUND:
The high prevalence of obesity in African-American (AA) women is of public health importance since AA women suffer higher mortality from cardiovascular and renal diseases than do white women. The reason for their marked susceptibility to obesity remains poorly understood though it is now known that AA women manifest lower resting energy expenditure than white women.
DESIGN NARRATIVE:
This is a multi-pronged metabolic and genetic epidemiologic study to examine two candidate genes (UCP3 and b3AR) implicated in energy metabolism. A total of 600 African American girls, aged 12-15 years, will be screened using buccal swabs as a non-invasive method of obtaining DNA, to determine their UCP3 genotypes as well as b3AR genotypes. An estimated 211 girls will be recruited, selected based on their UCP3 genotype, for measurements of resting energy expenditure and body composition (using dual energy X-ray absorptiometry [DEXA]) in a controlled setting of the Clinical Research Center at the Cincinnati Children's Hospital. Variation in resting energy expenditure will be examined across the genotypes of UCP3 with a large sample. The 2x3 design will allow the investigators to examine whether the effects associated with UCP3 variation are due to the UCP3 locus alone or due to the additive effect or interaction between UCP3 and b3AR. The study will help to elucidate the relationship between variation in two important candidate genes for energy metabolism, UCP3 and b3AR, and inter-individual variation in the levels of resting energy expenditure in this very high risk (for obesity) population.
日期
最后验证: | 12/31/2013 |
首次提交: | 04/10/2001 |
提交的预估入学人数: | 04/10/2001 |
首次发布: | 04/11/2001 |
上次提交的更新: | 01/08/2014 |
最近更新发布: | 01/09/2014 |
实际学习开始日期: | 04/30/2001 |
预计主要完成日期: | 03/31/2008 |
预计完成日期: | 03/31/2008 |
状况或疾病
相
资格标准
有资格学习的年龄 | 12 Years 至 12 Years |
有资格学习的性别 | Female |
取样方式 | Probability Sample |
接受健康志愿者 | 是 |
标准 | No eligibility criteria |
结果
主要结果指标
1. UCP3 genotype correlation to obesity [six months]