Giant Cell Tumor of the Bone in Young Patients
关键词
抽象
日期
| 最后验证: | 05/31/2019 |
| 首次提交: | 06/24/2019 |
| 提交的预估入学人数: | 06/25/2019 |
| 首次发布: | 06/30/2019 |
| 上次提交的更新: | 02/10/2020 |
| 最近更新发布: | 02/11/2020 |
| 实际学习开始日期: | 06/04/2019 |
| 预计主要完成日期: | 12/29/2019 |
| 预计完成日期: | 06/04/2020 |
状况或疾病
相
资格标准
| 有资格学习的性别 | All |
| 取样方式 | Non-Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: 1. Male and female patients under 15 years old treated at Rizzoli Institute from 01 January 1982 to 31 December 2018. 2. Diagnosis of giant cell tumor of bone, aneurysmatic bone cysts with solid features and giant cell reparative granuloma. 3. Histological slides/formalin-fixed paraffin-embedded tissue tumor blocks from archive available to perform the histology analysis 4. Written informed consent prior to any study-specific analysis and/or data collection Exclusion Criteria: 1. Patients with histological diagnosis different from diagnosis of giant cell tumor, aneurysmatic bone cysts with solid features, and giant cell reparative granuloma. 2. Patients with no available material for additional immunohistochemical and molecular analysis |
结果
主要结果指标
1. selection and review of 50 cases of young patients with Giant Cell Tumor of bone. [at baseline (Day0)]
次要成果指标
1. analysis of H3F3A mutation expression on tissue tumor material [at baseline (Day0)]
