Glycemic Effects of Honey
关键词
抽象
描述
Glucose intolerance and insulin resistance are associated with the development of the metabolic syndrome and chronic diseases, including, hyperlipidemia, hypertension, obesity, and type II diabetes. Current National Institutes of Health statistics estimate that 1 in 6 Americans have insulin resistance (www.diabetes.niddk.nih.gov/dm/pubs/statistics). Insulin resistance in humans is associated with glucose intolerance, enhanced oxidative stress, inflammation and alterations in lipid profiles. Improvements in glucose tolerance are associated with improved insulin sensitivity resulting in improved inflammatory and oxidative status. Dietary modification to reduced day-long serum insulin concentration is postulated to decrease hepatic cholesterol production through inhibition of HMG CoA reductase, the rate limiting enzyme involved in cholesterol synthesis.
Maintenance of normal blood glucose is dependent on the body's ability to modulate insulin secretion in response to the glucose load consumed. Although diet may be an important factor in glucose tolerance, the role of nutritive sweeteners has not been clearly defined. Much research has been performed on the effect of dietary sugars on chronic disease risk factors, including animal studies, and human studies ranging from epidemiologic to controlled feeding trials with most of this work focused on the monosaccharides: fructose and glucose or the disaccharide, sucrose.
Little work has been done on the comparative effects of honey and other nutritive sweeteners in relation to glucose tolerance and insulin sensitivity.
日期
最后验证: | 07/31/2018 |
首次提交: | 06/02/2011 |
提交的预估入学人数: | 06/07/2011 |
首次发布: | 06/09/2011 |
上次提交的更新: | 07/31/2018 |
最近更新发布: | 08/02/2018 |
实际学习开始日期: | 05/31/2011 |
预计主要完成日期: | 11/30/2014 |
预计完成日期: | 07/31/2015 |
状况或疾病
干预/治疗
Dietary Supplement: Honey
Dietary Supplement: High Fructose Corn Syrup 55 (HFCS 55)
Dietary Supplement: CHO (sugar)
相
手臂组
臂 | 干预/治疗 |
---|---|
Active Comparator: Honey 60.7 grams daily orally times 14 days | |
Active Comparator: CHO 50 grams daily orally times 14 days | |
Active Comparator: High Fructose Corn Syrup 65.7 grams daily orally times 14 days |
资格标准
有资格学习的年龄 | 20 Years 至 20 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: 1. Men and women between 20-80 years of age. 2. Normal Glucose Tolerance - Fasting glucose between ≤105 mg/dl - Normal body weight or overweight (BMI 18-29.9) 3. Impaired Glucose Tolerance - Fasting glucose between 106-125 mg/dl - Overweight or obese (BMI 25 - 39.9) 4. Willingness to comply with the demands of the experimental protocol 5. Sedentary Lifestyle Exclusion Criteria: 1. Known uncontrolled disease process 2. Diabetes mellitus 3. Use of medications that affect glucose metabolism 4. History of an eating disorder 5. Pregnancy or breast feeding 6. Inability to give consent 7. Unwillingness or inability to consume the supplemental sugars |
结果
主要结果指标
1. Area under the curve glucose, response for OGTT. Glucose-120 min OGTT-AUC [15 weeks]
次要成果指标
1. Insulin- 120 min OGTT - AUC [15 weeks]
2. Triglycerides - 120 min OGTT - AUC [15 weeks]
3. Inflammatory Markers [15 weeks]
4. Oxidative Stress Markers [15 weeks]
5. Serum Lipids [15 weeks]