Heart Aging When Near Vision Difficulty Begins
关键词
抽象
描述
Lens cells and proteins are encapsulated, and they are not turned over or replaced.The lens nucleus starts to form before birth, so the nucleus is one of the three oldest tissues in the body .With aging, continuous cardiomyocyte stress derails proteostasis by causing excessive autophagy and protease activation, and, ultimately, contractile and electrophysiological dysfunction. Aggregate deposition, proteostasis deterioration, and diffusion degradation between the nucleus and cortex are the main reasons for lens aging.Heart, lens, and neuronal cells change significantly with age, and they are older than cells from renewable tissues.
Near vision deterioration during aging results from a decrease in accomodation amplitude (AA). Cardiac aging is an independent risk factor for cardiovascular disease. Thus, the investigators investigated the association between cardiac aging and AA. The subjects (500 mean 50-year-old subjects, with equal males and females) were divided into two groups according to AA measured with a Raf ruler. The nucleus diameter change at 1 D accomodation was measured using ImageJ. Cardiac conduction system differences, autonomic aging, myocardial aging were evaluated using electrocardiography, heart rate variability and diastolic dysfunction. For near distance vision,compared to subjects who could see clearly from 24-28 cm, subjects who could see clearly from 29-33 cm had a 2.104-fold higher risk of a lateral e' velocity <10 cm/s[95%CI; 1.312-3.374], 2.603-fold higher risk of diastolic dysfunction[95%CI; 1.453-4.662], 1.54-fold higher risk of a low/high frequency ratio >3.1, [95%CI;1.085-2.197]. Subjective AA measurement can predict important heart aging parameters.
日期
最后验证: | 03/31/2020 |
首次提交: | 04/19/2020 |
提交的预估入学人数: | 04/22/2020 |
首次发布: | 04/23/2020 |
上次提交的更新: | 04/22/2020 |
最近更新发布: | 04/23/2020 |
实际学习开始日期: | 09/09/2019 |
预计主要完成日期: | 03/14/2020 |
预计完成日期: | 03/14/2020 |
状况或疾病
干预/治疗
Diagnostic Test: Subjective accomodation amplitude measurement
相
手臂组
臂 | 干预/治疗 |
---|---|
High AA group Group 1 consisted of those having an AA level of 3.57-4.16 D (high AA group; those who had near clear vision between 24-28 cm). . | |
Low AA group Group 2 consisted of those having an AA level of 3.44-3.03 D (low AA group; those who had near clear vision between 29-33 cm) |
资格标准
有资格学习的年龄 | 49 Years 至 49 Years |
有资格学习的性别 | All |
取样方式 | Non-Probability Sample |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: Healthy Volunteers, mean 50 years of age (49-51) Exclusion Criteria: Hypertension, Diabetes mellitus, Atrial fibrillation, Coronary artery disease, Arrhythmia, Hyperthyroidism , Anemia, Heart failure, Respiratory diseases, Severe obesity (body mass index ≥35 kg/m2), |
结果
主要结果指标
1. ECG interval changes meauserements(ms,mm,number) [1 day]
2. Holter implementation [1 day]
3. Echocardiographic measurements [1 day]