Impact of Uterotonic Agents on Isolated Human Myometrium
关键词
抽象
描述
Postpartum hemorrhage (PPH) is a major cause of maternal mortality and morbidity. In 80% cases of PPH, the primary cause is failure of the uterus to contract after delivery of the baby, which then requires further treatment of the mother with uterotonic drugs (drugs used to contract uterus and thus prevent bleeding).
Patients participating in this study will be asked to donate a very small sample of uterine tissue during Cesarean section, which will be tested for the ability to contract after treatment with various uterotonic drugs (oxytocin, ergonovine and carboprost) in the laboratory. This information will help us know the effect of these drugs by comparing the contractile capability of the uterine tissue.
日期
| 最后验证: | 01/31/2014 |
| 首次提交: | 07/28/2009 |
| 提交的预估入学人数: | 09/30/2009 |
| 首次发布: | 10/01/2009 |
| 上次提交的更新: | 02/18/2014 |
| 最近更新发布: | 02/19/2014 |
| 实际学习开始日期: | 05/31/2007 |
| 预计主要完成日期: | 07/31/2013 |
| 预计完成日期: | 07/31/2013 |
状况或疾病
干预/治疗
Drug: Treatment
Drug: Treatment
Drug: Treatment
Drug: Treatment
Drug: Treatment
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| No Intervention: No treatment A control sample from each patient (no uterotonic drug applied) will be measured concurrently with samples treated with various drugs. | |
| Active Comparator: Treatment Samples from each patient will be bathed in solutions containing varying concentrations of either oxytocin, carboprost and ergonovine, and contractility will be measured. | Drug: Treatment Oxytocin, 10-9mol/L to 10-3mol/L, in Krebs-Henseleit solution. |
资格标准
| 有资格学习的性别 | Female |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Gestational age 37-41 weeks - Non-laboring patients, not exposed to exogenous oxytocin - Patients requiring primary Cesarean section - Cesarean section under spinal anesthesia Exclusion Criteria: - Patients who require general anesthesia - Patient who had previous uterine surgery or Cesarean section - Patients with placental anomalies - Emergency Cesarean section in labor - Patients with bleeding disorders |
结果
主要结果指标
1. Amplitude of contraction [6-8 hours]
次要成果指标
1. Integrated area under response curve (AUC) [6-8 hours]
2. Basal tone [6-8 hours]
3. Frequency of contraction [6-8 hours]
