Intervention With Legume Kernel Fibre in Healthy Subjects
关键词
抽象
描述
Dietary fibre is suspected to effect the faecal concentration and excretion of bile acids by binding the bile acids and by increasing the faecal mass. Bile acids, especially the secondary bile acids, are potential risk factors for colorectal cancer. A high bile acid-binding ability of fibre could lead to lower serum cholesterol concentrations by interrupting the enterohepatic circulation. There is evidence that the consumption of legume kernel fibre, containing both soluble and insoluble fibre fractions, may beneficially modify bowel health.
Seventy-eight healthy volunteers were enrolled. Seventy-six subjects (mean age of 24 years, 55 women and 21 men) completed the double-blind, randomized crossover trial. After two weeks run-in period, half of the volunteers consumed 25 g of legume fibres (Boregine, TypTop or Soy fibre) every day, and the other half received a reference fibre product (citrus fibre, Herbacel AQ Plus) for a period of two weeks. After two weeks wash-out the intervention changed between the groups.
At the end of each period a quantitative stool and urine collection took place and fasting blood samples were drawn.
日期
最后验证: | 11/30/2009 |
首次提交: | 12/16/2009 |
提交的预估入学人数: | 12/17/2009 |
首次发布: | 12/20/2009 |
上次提交的更新: | 11/04/2012 |
最近更新发布: | 11/05/2012 |
实际学习开始日期: | 06/30/2007 |
预计主要完成日期: | 11/30/2007 |
预计完成日期: | 11/30/2007 |
状况或疾病
干预/治疗
Dietary Supplement: pure fibre-product
Dietary Supplement: reference fibre
相
手臂组
臂 | 干预/治疗 |
---|---|
Experimental: TypTop Lupinus albus Typ Top (lupin kernel fibre, dietary fibre content: 83%) | |
Experimental: Soy fibre Glycine max Hefeng (soy fibre; dietary fibre content: 77%) | |
Experimental: Boregine Lupinus angustifolius Boregine (lupin kernel fibre, dietary fibre content: 87%) |
资格标准
有资格学习的年龄 | 20 Years 至 20 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - age 20-45 years - healthy subjects Exclusion Criteria: - intake of pharmaceuticals and nutritional supplements - allergy against legumes - intolerance against milk protein - pregnancy, lactation - chronic diseases |
结果
主要结果指标
1. Changes of serum lipids (cholesterol metabolism) [after 2, 4 and 8 weeks]
次要成果指标
1. Changes of general excretion parameters, neutral sterols, bile acids, short-chain fatty acids, fibre excretion [after 2, 4 and 8 weeks]