Intervention With Lupin Kernel Fibre in Hypercholesterolemic Subjects
关键词
抽象
描述
Dietary fibre is suspected to effect the faecal concentration and excretion of bile acids by binding the bile acids and by increasing the faecal mass. Bile acids, especially the secondary bile acids, are potential risk factors for colorectal cancer. A high bile acid-binding ability of fibre could lead to lower blood cholesterol concentrations by interrupting the enterohepatic circulation. There is evidence that the consumption of lupin kernel fibre, containing both soluble and insoluble fibre fractions, may beneficially modify bowel health.
A total of 133 subjects were recruited for this study. Sixty moderate hypercholesterolemic volunteers (total cholesterol > 5.2 mmol/L) fulfilled the selection criteria and were randomly assigned three groups. Forty-five subjects (mean age of 47 years, 34 women and 20 men) completed the double-blind, randomized crossover trial.
The subjects consumed a high-fibre diet containing 25 g fibre (citrus- or lupin fibre) per day and a low-fibre diet (placebo) for four weeks each. After baseline, each volunteer had to pass all three periods in different order with a two-week wash-out period between each.
At the end of each intervention period, subjects consumed a standardized diet for three days. Furthermore, a quantitative stool collection took place and fasting blood samples were drawn.
日期
| 最后验证: | 11/30/2012 |
| 首次提交: | 12/16/2009 |
| 提交的预估入学人数: | 12/16/2009 |
| 首次发布: | 12/17/2009 |
| 上次提交的更新: | 12/03/2012 |
| 最近更新发布: | 12/04/2012 |
| 实际学习开始日期: | 05/31/2008 |
| 预计主要完成日期: | 11/30/2008 |
| 预计完成日期: | 11/30/2008 |
状况或疾病
干预/治疗
Dietary Supplement: fabricated food
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: Boregine Intervention: Lupinus angustifolius Boregine; 25 g lupin kernel fibre per day over 4 weeks; lupin kernel fibre was incorporated in different food | |
| Active Comparator: Reference Intervention: Reference fibre (citrus fibre: Herbacel AQ Plus; Herbafood ingredients); 25 g citrus fibre per day over 4 weeks; the citrus fibre was incorporated in different food | |
| Placebo Comparator: Placebo different food without added fibre |
资格标准
| 有资格学习的年龄 | 20 Years 至 20 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - moderate Hypercholesterolemia (total cholesterol > 5.2 mmol/L) - age 20-75 years Exclusion Criteria: - intake of lipid-lowering pharmaceuticals - intake of nutritional supplements - allergy against legumes - intolerance against milk protein - pregnancy, lactation - chronic bowel diseases |
结果
主要结果指标
1. cholesterol metabolism (blood lipids) [after 1, 5, 10 and 15 weeks]
次要成果指标
1. general excretion parameters, neutral sterols, bile acids, short-chain fatty acids, fibre excretion, cytotoxicity, genotoxicity [after 1, 5, 10 and 15 weeks]
