Involvement of Nervous System in Muscle Weakness in COPD Patients
关键词
抽象
描述
COPD is a common disease that induces many systemic repercussions. Among these, peripheral muscle dysfunction is particularly deleterious because it leads to the decreases of the level of activity and the quality of life for patients. Movement involves activation of many structures, from the instructor, i.e. the brain, to the effector, i.e. the muscle. Netherless, the studies which have described peripheral muscle dysfunction have been focused on the muscle, so they have proposed a reducing vision of the phenomenon. Other studies have reported cerebral alterations in COPD, like cognitive disturbance, increase of the neuronal conduction time, and decrease of the white matter density, and were associated with chronic hypoxemia. Such alterations are consistent with the existence of a decrease of the central motor drive during voluntary movement in COPD patients. Therefore the study will aim to determine precisely which mechanisms are involved in peripheral muscle dysfunction in copd.
日期
最后验证: | 02/28/2015 |
首次提交: | 09/02/2012 |
提交的预估入学人数: | 09/02/2012 |
首次发布: | 09/05/2012 |
上次提交的更新: | 03/08/2015 |
最近更新发布: | 03/09/2015 |
实际学习开始日期: | 06/30/2012 |
预计主要完成日期: | 03/31/2014 |
预计完成日期: | 03/31/2014 |
状况或疾病
相
手臂组
臂 | 干预/治疗 |
---|---|
COPD nocturnal desaturator COPD patients who spend 30% of the nigth with a SaO2 < 90%. | |
COPD no nocturnal desaturator COPD patients who spend less than 30% of the night with a SaO2 < 90% | |
control group healthy sedentary subjects |
资格标准
有资格学习的年龄 | 40 Years 至 40 Years |
有资格学习的性别 | All |
取样方式 | Non-Probability Sample |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - COPD Patients at stage 2 and 3 - Healthy sedentary subjects Exclusion Criteria: - Epilepsy, pace-maker, nervous disorders |
结果
主要结果指标
1. Level of voluntary activation [2h]