Ischemic Preconditioning at a Distance in Liver Surgery
关键词
抽象
日期
| 最后验证: | 10/31/2019 |
| 首次提交: | 11/19/2019 |
| 提交的预估入学人数: | 11/26/2019 |
| 首次发布: | 11/28/2019 |
| 上次提交的更新: | 11/26/2019 |
| 最近更新发布: | 11/28/2019 |
| 实际学习开始日期: | 01/31/2020 |
| 预计主要完成日期: | 01/31/2021 |
| 预计完成日期: | 01/31/2021 |
状况或疾病
干预/治疗
Procedure: Inflation of a pneumatic tourniquet
Other: No inflation
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: Inflation of a pneumatic tourniquet | Procedure: Inflation of a pneumatic tourniquet a pneumatic tourniquet around 200 mmHg after venous chase of the lower limb, during 5 minutes then deflated. Repeated twice after general anaesthesia and prior to incision. |
| Sham Comparator: No inflation No inflation of the pneumatic tourniquet placed on the lower limb | Other: No inflation No inflation of the pneumatic tourniquet placed on the lower limb |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Scheduled carcinogenic laparoscopy or laparotomy liver resection - Insured under the social security system - Inclined to comply to the study protocol and its duration. Exclusion Criteria: - Patient under guardianship - Pregnancy or breastfeeding - Severe lower limb vascular disease - Emergency surgery - Contraindication of a treatment from the protocol - Psychological disorder with difficulty to accede the protocol - Absence of written informed consent - Refusal to sign the protocol - Non-registration to the social security system |
结果
主要结果指标
1. Indocyanine green clearance [at 5 days after liver resection]
次要成果指标
1. Serum transaminases rates [at day 1,day 3 and day 5 post-hepatectomy.]
2. Prothrombin rate [at day 5 post-hepatectomy.]
3. the Kidney Disease: Improving Global Outcomes (KDIGO) score [at day 1,day 3 and day 5 post-hepatectomy.]
4. the Clavien & Dindo score [at day 30 post-hepatectomy]
5. duration of stay in the hospital. [at day 30 post-hepatectomy]
