Laryngeal Adaptation for Speech and Swallowing
关键词
抽象
日期
| 最后验证: | 08/31/2019 |
| 首次提交: | 11/28/2018 |
| 提交的预估入学人数: | 12/05/2018 |
| 首次发布: | 12/09/2018 |
| 上次提交的更新: | 09/05/2019 |
| 最近更新发布: | 09/09/2019 |
| 实际学习开始日期: | 08/23/2018 |
| 预计主要完成日期: | 08/29/2019 |
| 预计完成日期: | 08/29/2019 |
状况或疾病
干预/治疗
Device: Intermittent Perturbation to Continuous Perturbation
Device: Continuous Perturbation to Intermittent Perturbation
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: Stroke without Dysarthria Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm. | |
| Experimental: Stroke with Dysarthria Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm. | |
| Experimental: SCA6 without Dysarthria Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm. | |
| Experimental: SCA6 with Dysarthria Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm. | |
| Active Comparator: Age-Matched Controls Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm. |
资格标准
| 有资格学习的年龄 | 21 Years 至 21 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Patient Inclusion Criteria: All stroke and ataxia Ataxia - DNA diagnosis of SCA6 and phenotype consistent with the DNA diagnosis - No recessive, X-linked or mitochondrial Stroke - Bilateral or unilateral middle cerebral artery (MCA) stroke - No structural abnormalities (i.e. nodules) - Dysphagia involving laryngeal dysfunction Stroke and ataxia with speech and swallowing disorders - no structural abnormalities - dysphagia involving laryngeal dysfunction Patient Exclusion Criteria: - Montreal Cognitive Assess. <24 - Moderate to severe hearing loss - Barium allergy - Other confounding speech disorder (i.e. stuttering) - Chemo-radiation, surgical head and neck treatment - Smoking Hx in the past 5 yrs or >5 years at any one time - Twenty one years of age or older - Breathing disorders or diseases |
结果
主要结果指标
1. Laryngeal Adaptation in Speech [Day 1]
2. Laryngeal Adaptation in Swallowing [Day 1]
