Late Sequelae of Bronchopulmonary Dysplasia
关键词
抽象
描述
BACKGROUND:
Eleven to 22 percent of prematurely born human infants with Respiratory Distress Syndrome (RDS) treated with artificial ventilation and supplemental oxygen therapy, develop a severe chronic lung disease called bronchopulmonary dysplasia. While many children who had BPD are asymptomatic by three years of age, some can have respiratory symptoms and abnormal pulmonary function tests at nine years of age. The hypothesis tested in this study is that abnormalities of pulmonary function seen in infants with BPD can persist into adolescence, even in asymptomatic children and young adults.
DESIGN NARRATIVE:
A detailed interval pulmonary history was taken. Pulmonary abnormalities were determined by pulmonary angiography and lateral chest x-ray and pulmonary function tests for small airway obstruction, reversible bronchial hyperreactivity, distribution of ventilation, air trapping and hyperinflation, residual interstitial disease or edema, vascular bed loss, and gas exchange. Right and left ventricular hypertrophy were evaluated by electrocardiogram. Elevated right ventricular pressure was estimated by echocardiography with doppler ultrasound. The atopic status of the children was determined. Other abnormalities, including growth retardation, developmental delay, hearing loss, retrolental fibroplasia, and neurologic disability seen in BPD were assessed by history and physical examination.
日期
最后验证: | 12/31/2015 |
首次提交: | 05/24/2000 |
提交的预估入学人数: | 05/24/2000 |
首次发布: | 05/25/2000 |
上次提交的更新: | 01/07/2016 |
最近更新发布: | 01/11/2016 |
实际学习开始日期: | 06/30/1986 |
预计完成日期: | 05/31/1989 |
状况或疾病
相
资格标准
有资格学习的性别 | Male |
接受健康志愿者 | 是 |
标准 | No eligibility criteria |