LGI1-antibody Patients Follow-up
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Hospices Civils de Lyon
临床试验: NCT04106765
BioSeek: nct04106765
关键词
抽象
Autoimmune encephalitis involve autoantibodies targeting central nervous system, and particularly the synapse or its structure like for LGI1 protein. Anti-LGI1 encephalitis is revealed by an inflammation of the limbic system, with mainly temporal lobe, faciobrachial dystonic or generalized seizures, and cognitive disorders.
This disease is rare and its clinical, EEG and radiological characterisation is not sufficiently established. The investigators will evaluate these three aspects for the anti-LGI1 cohort of patients of the National Reference Center of autoimmune encephalitis.
日期
| 最后验证: | 08/31/2019 |
| 首次提交: | 09/24/2019 |
| 提交的预估入学人数: | 09/25/2019 |
| 首次发布: | 09/26/2019 |
| 上次提交的更新: | 10/10/2019 |
| 最近更新发布: | 10/14/2019 |
| 实际学习开始日期: | 10/29/2019 |
| 预计主要完成日期: | 09/29/2020 |
| 预计完成日期: | 12/29/2020 |
状况或疾病
Anti-LGI1 Encephalitis
相
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手臂组
| 臂 | 干预/治疗 |
|---|---|
| : epileptic LGI1-antibody patients Patients affected by LGI1 antibody encephalitis presenting epileptic seizures as a first symptom
Evaluated items:
Number of seizures
Type of seizures
Presence of EEG abnormalities
Presence of IRM abnormalities
Time before cognitive disorders | |
| cognitive LGI1-antibody patients Patients affected by LGI1 antibody encephalitis presenting cognitive disorders as a first symptom
Evaluated items:
Presence of EEG abnormalities
Presence of IRM abnormalities
Time before epileptic seizures |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 取样方式 | Non-Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Age > 18 years - Diagnosis of anti-LGI1 encephalitis based on sera or CSF samples in the National Reference Center of autoimmune encephalitis from 2011/06 to 2019 july 1st. - Clinical follow-up in France Exclusion Criteria: - Anti-LGI1 antibody associated with another encephalitis antibody - Foreign follow-up |
结果
主要结果指标
1. Evolution of epileptic seizures [12 MONTHS]
