Lippia Alba for Migraine Prophylaxis and Treatment
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Fabio Carmona
临床试验: NCT01259947
BioSeek: nct01259947
关键词
抽象
Abstract Background: There is no universally accepted and effective prophylaxis of migraine headache episodes. Thus the investigators aimed to investigate the effects of Lippia alba (Mill.) N. E. Brown, an herb with many effects on central nervous system, on pain frequency and intensity of migraine patients.
Methods: Patients were enrolled in a prospective, phase 2, non-controlled cohort study to orally receive ethanolic extract of L. alba leaves (1-2 drips/kg/day). Headache intensity and frequency of episodes were recorded before and after 30-60 days of treatment. The investigators also studied the chemical composition of its essential oil by gas chromatography-mass spectrometry.
Results: The investigators described for the first time a particular L. alba chemotype with geranial and carvenone as major compounds. With treatment, both frequency and intensity of pain episodes significantly decreased from baseline to first reassessment date. More than 80% of patients experienced a minimum 50% reduction on pain intensity and frequency. No side effects were reported.
Conclusions: Treatment with a geranial plus carvenone chemotype of L. alba ethanolic extract is a cheap, widely available, highly effective therapy to reduce both the intensity and the frequency of headache episodes of migraine patients with no side effects.
Keywords: headache, migraine, medicinal plant, essential oil, phytotherapy
日期
最后验证: | 12/31/2015 |
首次提交: | 12/13/2010 |
提交的预估入学人数: | 12/13/2010 |
首次发布: | 12/14/2010 |
上次提交的更新: | 01/25/2016 |
最近更新发布: | 01/26/2016 |
实际学习开始日期: | 06/30/2006 |
预计主要完成日期: | 03/31/2010 |
预计完成日期: | 09/30/2010 |
状况或疾病
Migraine Disorders
干预/治疗
Drug: Lippia alba
相
相 2
手臂组
臂 | 干预/治疗 |
---|---|
Experimental: Lippia alba | Drug: Lippia alba 1-2 drops per kilogram per day, PO, twice a day |
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Migraine diagnostic Exclusion Criteria: - Patient's request |