Liver Injury in Patients With COVID-19
关键词
抽象
描述
Scenario Multicenter study of patients hospitalized with SARS-CoV-2 in different institutions in Latin America and directed by the Coronavirus and Liver interest group of the Latin American Association for the Study of the Liver (ALEH), coordinated by Dr. Marcelo Silva. This project has been presented to ALEH, which has considered it of high interest and will promote its dissemination among partners and related Associations with the aim of obtaining the greatest participation from the centers in the region.
Design Observational cross-sectional study to describe the prevalence of liver disease in patients hospitalized for SARS-CoV-2. The administrative period of the study will be from 04/25/20 to 12/15/20. The enrollment date of the patients will be the date of the diagnosis of SARS-CoV-2 infection and the date of end of follow-up will be the day of hospital discharge, referral to another center or death.
Participating centers will identify patients who meet the selection criteria during the study period. The diagnosis of SARS-CoV-2 can be made at any time during hospitalization. All included patients will be evaluated and treated according to the specific protocol of each institution. The follow-up period will run until the day of hospital discharge or death.
A specific coded form will be prepared for data registration, which will be subsequently downloaded to a computerized database for subsequent analysis. The exposure variables included in the form will be collected by the investigating doctors.
The following study will be performed following international recommendations for observational studies STROBE guidelines
日期
| 最后验证: | 06/30/2020 |
| 首次提交: | 04/17/2020 |
| 提交的预估入学人数: | 04/20/2020 |
| 首次发布: | 04/23/2020 |
| 上次提交的更新: | 07/18/2020 |
| 最近更新发布: | 07/20/2020 |
| 实际学习开始日期: | 04/14/2020 |
| 预计主要完成日期: | 12/30/2020 |
| 预计完成日期: | 12/30/2020 |
状况或疾病
干预/治疗
Other: Patients with Liver Injury
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Patients without Liver Injury Hospitalized patients with COVID-19 disease who did not develop liver injury | |
| Patients with Liver Injury Hospitalized patients with COVID-19 disease who develop liver injury | Other: Patients with Liver Injury LFTs elevation or liver decompensation |
资格标准
| 有资格学习的年龄 | 17 Years 至 17 Years |
| 有资格学习的性别 | All |
| 取样方式 | Non-Probability Sample |
| 接受健康志愿者 | 没有 |
| 标准 | Inclusion Criteria: - Patients older than 17 years - Patients with diagnosis of SARS-CoV-2 infection - Hospitalized patients Exclusion Criteria: - |
结果
主要结果指标
1. Liver injury in patients with COVID-19 [through study completion, an average of 6 months]
次要成果指标
1. Prognostic factors associated with death [through study completion, an average of 6 months]
2. Clinical characteristics of patients who developed liver injury [through study completion, an average of 6 months]
