Melatonin and Coronary Artery Calcification
关键词
抽象
描述
Coronary artery calcification (CAC) is prevalent in coronary artery disease (CHD), and the extent of CAC predicts cardiovascular risk. The causes of CAC include dysregulated matrix metabolism, epitaxial mineral deposition, inflammation, oxidative stress, and apoptosis. Melatonin is the main indoleamine produced by the pineal gland; it is known recently to have anti-inflammatory, anti-cancer and antioxidant activities. Several studies have shown that melatonin protects against inflammation and apoptosis in vascular calcification. Melatonin also inhibits oxidative stress-induced apoptosis and calcification in endplate chondrocytes. However, no study has evaluated whether melatonin is associated with CAC in patients with coronary atherosclerosis. The investigators planned to research the association between plasma melatonin and coronary artery calcification.
日期
| 最后验证: | 04/30/2019 |
| 首次提交: | 05/25/2019 |
| 提交的预估入学人数: | 05/27/2019 |
| 首次发布: | 05/29/2019 |
| 上次提交的更新: | 05/27/2019 |
| 最近更新发布: | 05/29/2019 |
| 实际学习开始日期: | 04/30/2017 |
| 预计主要完成日期: | 04/29/2019 |
| 预计完成日期: | 04/29/2019 |
状况或疾病
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| plasma melatonin 1 Quartile 1 of plasma melatonin | |
| plasma melatonin 2 Quartile 2 of plasma melatonin | |
| plasma melatonin 3 Quartile 3 of plasma melatonin | |
| plasma melatonin 4 Quartile 4 of plasma melatonin |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 取样方式 | Probability Sample |
| 接受健康志愿者 | 没有 |
| 标准 | Inclusion Criteria: Patients with angina-like chest pain, were included in this study. All subjects had blood samples collected and all underwent a coronary CTA scan. Exclusion Criteria: 1. melatonin treatment 2. coronary revascularization (percutaneous coronary intervention or coronary artery bypass graft surgery) 3. heart failure or cardiomyopathies 4. hepatic failure 5. renal dysfunction 6. haemolytic disorders 7. thyroid disease 8. neoplastic diseases 9. acute infectious or inflammatory conditions. |
结果
主要结果指标
1. correlations of CAC score with melatonin concentrations [Subjects underwent a CAC scan at baseline.]
次要成果指标
1. correlations of CAC score with high-sensitivity C-reactive protein (hsCRP) level [Subjects had blood samples collected at baseline.]
2. correlations of CAC score with malondialdehyde (MDA) level [Subjects had blood samples collected at baseline.]
