Metabolic Studies- Interactions Between GH and Insulin in GHDA
关键词
抽象
描述
Insulin resistance is a pathophysiological component of type 2 diabetes, obesity and elevated blood pressure. Overall they are syndromes with multifactorial ethology and partly unclarified pathophysiology. Insulin resistance also occur in more seldom diseases with a more unified pathogenesis. Growth hormone deficiency (GHD) in adults with hypopituitarism is an example of one of those seldom diseases. Prolonged GHD is associated with abdominal overweight, dyslipidemia and increased cardiovascular morbidity. Besides, GHD-patients have decreased insulin sensitivity presumably secondary to the altered body composition. Long term effects of GH-substitution improves insulin sensitivity but it is well-known that subcutaneous administration of GH acute worsen insulin sensitivity in both muscles- and liver-tissue. Recently it has been reported that insulin resistance in patients with type 2 diabetes is associated with the induction of a signal protein called suppressor of cytokine signalling (SOCS). It´s interesting that GH also induces a stimulation of SOCS.
日期
最后验证: | 12/31/2012 |
首次提交: | 12/04/2007 |
提交的预估入学人数: | 12/04/2007 |
首次发布: | 12/05/2007 |
上次提交的更新: | 01/17/2013 |
最近更新发布: | 01/20/2013 |
实际学习开始日期: | 11/30/2007 |
预计主要完成日期: | 01/31/2010 |
预计完成日期: | 01/31/2010 |
状况或疾病
干预/治疗
Drug: Growth hormone
相
手臂组
臂 | 干预/治疗 |
---|---|
Experimental: Growth hormone | Drug: Growth hormone GH infusion from 8.00 pm to 03.00 am (dose 10,2 ng/kg/min) c) GH infusion from 02.00 am to 09.00 am (dose 10,2 ng/kg/min). |
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | Male |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Written consent before study start - Growth Hormone substitution in stable dosis for at least 3 months prior to study start - Other substitution in stable dosis for at least 3 months prior to study start Exclusion Criteria: - Medical treatment for diabetes - Hypertension even with medical treatment - BMI > 30 - Excessive alcohol abuse |
结果
主要结果指标
1. Socs 1-3 activity in muscle tissue and degree of insulin resistance [6 hours]
次要成果指标
1. Growth Hormone Signaling Proteins in Muscle Tissue and other Insulin Signaling Proteins in Muscle Tissue [6 hours]