Methylenetetrahydrofolate Reductase Deficiency in Ischemic Stroke
关键词
抽象
描述
Epileptic seizures that begin in adulthood seriously affect patients, their relatives and the society in which they live financially and psychologically. The etiology of epileptic seizures starting at adult age includes head trauma, central nervous system infections, intracranial lesions, cerebrovascular events, metabolic diseases and drugs. While the causes of childhood epileptic seizures are generally considered idiopathic, adult-onset epileptic seizures are almost always due to a pathological process. Epileptic seizures in adults may be a symptom of ischemic stroke. MTHFR deficiency is associated with raised homocysteine concentration in the body and increased risk of stroke (1). Studies have demonstrated that hyperhomocysteinemia is an independent risk factor for stroke (2).
MTHFR is the key enzyme in remethylation of homocysteine to methionine. MTHFR deficiency is an autosomal-recessive disease characterized by high homocysteine and low or normal methionine. MTHFR deficiency can cause vascular thrombosis in adults at early age; increased osteoporosis in elderly people; deep vein thrombosis, abortus during pregnancy; and infertility in adult males. In children, it is associated with intrauterine growth retardation, congenital heart diseases, neural tube defects, chromosome anomalies and hematologic tumors. In any age group, it might cause convulsions, increased thrombosis risk with some anticonvulsants and with the use of nitrogen protoxide in surgeries, and neuromotor retardation (3).
The aim of this retrospective study is to investigate the incidence of MTHFR deficiency in patients presenting with adult-onset epileptic seizures and diagnosed as ischemic cerebrovascular disease as a result of diagnostic tests.
日期
最后验证: | 01/31/2020 |
首次提交: | 02/21/2020 |
提交的预估入学人数: | 02/24/2020 |
首次发布: | 02/26/2020 |
上次提交的更新: | 02/24/2020 |
最近更新发布: | 02/26/2020 |
实际学习开始日期: | 10/30/2019 |
预计主要完成日期: | 02/14/2020 |
预计完成日期: | 02/19/2020 |
状况或疾病
干预/治疗
Genetic: Adult patients who have epileptic seizures
相
手臂组
臂 | 干预/治疗 |
---|---|
Other: Adult patients who have epileptic seizures Patients with adult-onset epileptic seizures and diagnosed ischemic stroke. | Genetic: Adult patients who have epileptic seizures To investigate the incidence of MTHFR deficiency in patients with adult-onset epileptic seizures and diagnosed ischemic stroke |
资格标准
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - The patients with adult-onset epileptic seizures and diagnosed ischemic stroke in 3 years period. Exclusion Criteria: - Pediatric patients with epileptic seizures |
结果
主要结果指标
1. Methylenetetrahydrofolate reductase (MTHFR) deficiency [Up to 6 weeks]