Molecular Mechanisms of Raspberries Effect on Insulin Resistance and Inflammation
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赞助商
Pennington Biomedical Research Center
合作者
National Processed Raspberry Council
Louisiana State University and A&M College
临床试验: NCT04306406
BioSeek: nct04306406
关键词
抽象
Red raspberries (Rubus idaeus) are a good source of health enhancing hydrolyzable and condensed tannins, flavonoids, anthocyanins, phenolic acids, rheosmin, potassium, carotenoids, vitamin C, and vitamin K1. Compared to other berries commonly consumed in the US, the health benefits of red raspberries to improve pre-diabetes mellitus (PDM) and type 2 diabetes have never been explored. The clinical study proposed in this project seeks to investigate the protective effect of whole red raspberries against insulin resistance, oxidative stress, and inflammation in PDM and type 2 diabetic patients. The in vitro study proposed in the project will assist in identifying the molecular mechanisms by which whole red raspberry protect islet cells against oxidative stress, insulin resistance and loss of cell function.
日期
最后验证: | 02/29/2020 |
首次提交: | 07/29/2019 |
提交的预估入学人数: | 03/09/2020 |
首次发布: | 03/11/2020 |
上次提交的更新: | 03/09/2020 |
最近更新发布: | 03/11/2020 |
实际学习开始日期: | 01/06/2015 |
预计主要完成日期: | 01/12/2017 |
预计完成日期: | 01/12/2017 |
状况或疾病
Inflammation
Insulin Resistance
干预/治疗
Other: Raspberry Smoothies
相
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手臂组
臂 | 干预/治疗 |
---|---|
Other: Raspberry Smoothies Single serving smoothies drink made with red raspberries to be consumed daily for two weeks | Other: Raspberry Smoothies Red raspberry smoothies drink |
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - type 2 diabetes Exclusion Criteria: - hypoglycemic agents - Pregnant or nursing a child - chronic medication that does not have a stable dose for greater than one month - anti-inflammatory medication - inflammatory disease |
结果
主要结果指标
1. Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) [2 weeks]
Ratio of fasting insulin and glucose
2. A high-sensitivity C-reactive protein (hs-CRP) measured in milligrams per liter [2 weeks]
Measure of systemic inflammation
次要成果指标
1. 3,4-Dihydroxyphenylacetic acid (DOPAC) measured in nanograms per milliliter [2 weeks]
Measure of systemic inflammation