Montmorency Cherry Juice and Uric Acid Metabolism
关键词
抽象
描述
Plasma and urinary uric acid concentration, plasma phytochemical content and inflammatory biomarkers will be measured in order to elucidate the effects of an acute dose of tart cherry juice on indices related to the condition of gout.
Participants will be required to attend the laboratory at a range of time points over two periods of 96 hours, separated by a 7 day washout period, to provide blood samples. In order to provide a baseline sample, participants will attend the laboratory in the morning following an overnight fast and voiding of any urine. Following this participants will be given 30mls (30 mls provides 323 mg/380 µmol of anthocyanins) of tart cherry juice or placebo, diluted with 60 mls of water to consume within 10 minutes. Participants will be required to consume identical dosages of the supplement immediately prior to evening meals and breakfasts (or same time each morning following blood sampling if non-breakfast eater) over the next 96 hours. Further blood and urine samples will be collected at 1, 2, 3, 5, 8, 24, 26, 48, 50, 72, 74 and 96 hours and will require participants to return to the laboratory at each of these time points. Following the first period of supplementation participants will complete a 7 day washout period in which they will not be required to attend the laboratory. Following the washout period they will repeat the supplementation period consuming the supplement they did not receive during the first period.
日期
最后验证: | 03/31/2013 |
首次提交: | 03/28/2013 |
提交的预估入学人数: | 04/01/2013 |
首次发布: | 04/04/2013 |
上次提交的更新: | 04/01/2013 |
最近更新发布: | 04/04/2013 |
实际学习开始日期: | 02/29/2012 |
预计主要完成日期: | 06/30/2012 |
预计完成日期: | 02/28/2013 |
状况或疾病
干预/治疗
Dietary Supplement: Montmorency cherry concentrate
相
手臂组
臂 | 干预/治疗 |
---|---|
Experimental: low dose Montmorency cherry concentrate, 30 mls | |
Experimental: higher dose Montmorency cherry concentrate, 60 mls |
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - apparently healthy males/females between the ages of 18-40 years Exclusion Criteria: - underlying clinical pathology |
结果
主要结果指标
1. Change in uric acid [0, 1, 2, 3, 5, 8, 24, 26, 48 hours]
次要成果指标
1. Change in C-reactive protein [0,1,2,3,5,8,24,26,48 hours]
其他成果措施
1. Change in anthocyanins, polyphenolics and creatinine [0,1,2,3,5,8,24,26,48 hours]