Neurologic Manifestations of COVID 19 in Children
关键词
抽象
描述
Early reports of COVID-19 indicate that adults experience a variety of neurological symptoms and diagnoses in approximately 36% of patients, including headaches, seizures, coma, encephalitis, and cerebrovascular events including ischemic stroke, intracranial hemorrhage, and cerebral venous sinus thromboses. In children, recent evidence highlights acute and long-term neurological manifestations due to other viral illnesses including Guillain Barre syndrome and neonatal microcephaly with Zika virus, encephalitis with H1N1 influenza, and acute flaccid paralysis with enterovirus-68. However, COVID-19 reports in children published thus far lack detailed information on the frequency and outcomes of neurological findings.
COVID-19 cases are rapidly rising internationally, with experts forecasting subsequent global surges and continued activity. Thus, it is imperative to accurately document prevalence and outcomes of the neurological aspects of COVID-19 specifically in children. Such data will serve to alert clinicians and families about the possibility that children may present with neurologic rather than "classic" symptoms of COVID-19 who nevertheless would warrant testing, and that neurologic events can occur subsequent to the diagnosis that may impact long-term outcomes (e.g., cognitive, emotional, physical health). The investigators anticipate that improved knowledge about neurologic manifestations in children will bolster personalized treatment and rehabilitation strategies to optimize child outcomes and inform future interventional studies.
日期
最后验证: | 04/30/2020 |
首次提交: | 04/29/2020 |
提交的预估入学人数: | 05/05/2020 |
首次发布: | 05/06/2020 |
上次提交的更新: | 05/05/2020 |
最近更新发布: | 05/06/2020 |
实际学习开始日期: | 04/28/2020 |
预计主要完成日期: | 12/30/2021 |
预计完成日期: | 12/30/2022 |
状况或疾病
干预/治疗
Other: Children <18
相
手臂组
臂 | 干预/治疗 |
---|---|
Children <18 Infants, children, and young adults age < 18 years
Admitted to the hospital with confirmed or presumed COVID-19 infection (includes admissions to emergency, ward, intensive care etc.) | Other: Children <18 No Intervention |
资格标准
有资格学习的性别 | All |
取样方式 | Probability Sample |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Infants, children, and young adults age < 18 years - Admitted to the hospital with confirmed or presumed COVID-19 infection (includes admissions to emergency, ward, intensive care etc.) Exclusion Criteria: - none |
结果
主要结果指标
1. Frequency of neurologic manifestations of COVID 19 among pediatric patients requiring hospital admission for confirmed or presumed COVID 19 [From date of hospital admission until the date of hospital discharge (including death), assessed up to 12 months]
次要成果指标
1. Associations between prescription of empiric COVID-19 directed therapies and patient characteristics and outcomes among children with or without neurologic manifestations and confirmed or presumed COVID-19 [From date of hospital admission until the date of hospital discharge (including death), assessed up to 12 months]