Newborns of Obese Mothers
关键词
抽象
描述
The study population concerned obese pregnant women (BMI ≥ 30 kg / m² before pregnancy) and their newborn and normal weight pregnant women (18.5 ≤IMC <25 kg/m²) and their newborn as control. Inclusion criteria were body mass index (BMI) ≥ 30 kg/m2 or 18.5 ≤ BMI < 25 kg/m2, 18 ≤ age ≤ 40 years, singleton pregnancy. Exclusion criteria were: 25 ≤ BMI <30 kg/m2, age < 18 or > 40 years, multiple pregnancy, first consultation after 18 WG, pregestational diabetes, obesity due to genetic disorder or secondary to intracranial tumor or radiotherapy, bariatric surgery, chronic diseases other than the obesity, inability to converse in French language. The matching criteria for controls were: age ± 5 years, primigravida or multigravida, duration of gestation ± 4 weeks.
The main objective of this project was to assess the independent effect of maternal obesity:
- on the weight and adipose tissue of newborn
- on the function of adipose tissue (production of leptin and adiponectin)
- on fetal growth factors (C-peptide, IGF-1)
- on carbohydrate metabolism of the newborn. Two maternities were involved in the study: Pitié Salpêtrière and Armand Trousseau, in Paris, France. This research was conducted over a 3 years period. The duration of participation of each woman corresponded to the duration of pregnancy care and duration of care for the newborn immediately after birth, usually the length of stay in the maternity.
The only differences compared to the usual care included:
- Additional oral glucose tolerance test at 32 weeks of gestation;
- Determination of fasting blood glucose during late pregnancy
- Maternal blood samples on arrival at the delivery room
- Drawing blood from the umbilical cord after section;
- Skinfold measurement of the newborn within 72 hours of life.
日期
| 最后验证: | 01/31/2016 |
| 首次提交: | 02/09/2016 |
| 提交的预估入学人数: | 02/09/2016 |
| 首次发布: | 02/11/2016 |
| 上次提交的更新: | 04/04/2016 |
| 最近更新发布: | 04/05/2016 |
| 实际学习开始日期: | 06/30/2010 |
| 预计主要完成日期: | 09/30/2013 |
| 预计完成日期: | 09/30/2013 |
状况或疾病
干预/治疗
Procedure: Obstetric management
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: Obese group | |
| Active Comparator: Normal Weight group |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: 1. - BMI ≥30 kg / m² or between 18.50 and 24.99 kg / m². 2. - Pregnant woman coming to the centre before 18 weeks of gestation. 3. - Age ≥ 18 and ≤ 40 years 4. - Single Pregnancy 5. - No constitutional or progressive disease other than obesity: inflammatory disease, epilepsy, pathology psychiatric, tumor... 6. - Informed written consent. Exclusion Criteria: 1. - Pregnant woman coming to the center after 18 weeks of gestation, BMI <18.5 kg / m² or between 25 and 29.99 Kg / m². 2. - Age <18 or> 40 years 3. - Multiple pregnancy 4. - Presence of a constitutional disease or progressive disease other than obesity. 5. - Patients who underwent obesity surgery type "bypass" or gastroplasty 6. - Obesity secondary to genetic disorder, intracranial lesions or pituitary radiotherapy 7. - not stabilized endocrine pathology. 8. - pregestational diabetes 9. - No affiliation to a social security scheme |
结果
主要结果指标
1. ponderal index measured by a balance [at birth]
2. skinfold's measure measured by a special clamp [at birth]
3. birthweight [at birth]
