Obesity, Inflammation and Oxidative Stress
关键词
抽象
描述
The long-term objective of this project is to identify nutritional factors that can reduce the inflammatory component of obesity. Therapies to minimize obesity-related comorbidities are needed, and targeting inflammation may help slow the progression of obesity towards cardiovascular disease and insulin resistance.
Adipose tissue is a source of inflammatory cytokines, and obesity is now viewed as a chronic, low-grade inflammatory state. Inflammation itself is a contributor to the chronic diseases associated with obesity. C-reactive protein (CRP) is a key marker of inflammation, and as a downstream marker it provides functional integration of upstream cytokine activation associated with inflammation. We have previously shown that vitamin C, but not vitamin E, reduces CRP in active and passive smokers and in nonsmokers. The reduction is seen primarily in persons with CRP ≥1.0 mg/L, the CDC threshold for elevated cardiovascular disease risk. We also found that 75% of obese nonsmokers had CRP ≥1.0 mg/L.
The important observation of reduction in elevated CRP by vitamin C now needs to be confirmed in a rigorous study with adequate sample size, to permit justifiable conclusions about the potential usefulness of this agent in reducing inflammation in the obese. We will conduct a placebo-controlled, randomized trial in 552 healthy obese individuals with moderate CRP elevations (CRP ≥1.0 mg/L). Participants will be randomized to either 1000 mg/day vitamin C or placebo for a period of 2 months. We will also characterize the pathways through which this effect takes place by measuring cytokines and oxidative stress.
This project is important because if our previous finding is confirmed in this population, it could offer a low-cost alternative to use of statins to reduce inflammation in persons without other risk factors.
日期
最后验证: | 10/31/2015 |
首次提交: | 12/07/2009 |
提交的预估入学人数: | 12/07/2009 |
首次发布: | 12/08/2009 |
上次提交的更新: | 11/29/2015 |
最近更新发布: | 12/01/2015 |
实际学习开始日期: | 12/31/2009 |
预计主要完成日期: | 06/30/2012 |
预计完成日期: | 06/30/2012 |
状况或疾病
干预/治疗
Dietary Supplement: Vitamin C
Dietary Supplement: Placebo
相
手臂组
臂 | 干预/治疗 |
---|---|
Placebo Comparator: Placebo Two tablets, daily, for 8 weeks | Dietary Supplement: Placebo Placebo tablet (two 500-mg tablets), 8 weeks |
Experimental: Vitamin C Two tablets, daily, for 8 weeks | Dietary Supplement: Vitamin C 1000 mg/day (two 500-mg tablets), 8 weeks |
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - BMI ≥ 30 - hsCRP ≥ 1 mg/L - Age 18+ - Member of Kaiser Permanente Health Plan of Northern California Exclusion Criteria: - Smoker - Unwilling to discontinue vitamin supplements for study duration - Unwilling/unable to use acetaminophen in place of OTC anti-inflammatory medications - Use of certain medications - History of certain medical conditions |
结果
主要结果指标
1. high-sensitivity C-reactive protein [After 8 weeks of intervention]
次要成果指标
1. CRP-related markers of inflammation and oxidative stress, including cytokines and F2-isoprostanes. [After 8 weeks of intervention.]