Palatability of Oral Rehydration Solutions
关键词
抽象
描述
In Canada, acute gastroenteritis remains a major cause of morbidity and hospitalizations. This, in large part, is due to an inability to realize the full benefits of oral rehydration therapy. Because oral rehydration solutions have a salty taste, many mild to moderate dehydrated children refuse to drink them. This has resulted in pediatricians recommending inappropriate solutions and the unnecessary administration of intravenous fluids. Although two meta-analyses have concluded that rice-based ORS (Enfalyte) is as or more effective than traditional ORS in reducing stool output, the palatability of different oral rehydration solutions have never been evaluated.
This will be the first prospective trial comparing the palatability of the most commonly recommended oral rehydration solutions, Pedialyte and Enfalyte with a newer solution, Pediatric Electrolyte. Both Pedialyte and Pediatric Electrolyte contain sucralose, dextrose, and fructose while Enfalyte contains rice syrup solids. Although the latter is as, or more effective than Pedialyte in reducing stool output, palatability may limit its use. Taste is important as children with gastroenteritis are frequently nauseated and may refuse to drink or vomit when consuming less palatable solutions.
We hypothesize that, compared to children who receive a rice-based ORS (Enfalyte), those who receive a sucralose ORS (Pediatric Electrolyte or Pedialyte) will report a higher mean taste score, will prefer to drink the sucralose sweetened ORS if they had to consume a larger volume, and are more likely to drink the entire volume they are provided.
日期
最后验证: | 03/31/2018 |
首次提交: | 05/28/2008 |
提交的预估入学人数: | 06/01/2008 |
首次发布: | 06/02/2008 |
上次提交的更新: | 04/15/2018 |
最近更新发布: | 04/16/2018 |
实际学习开始日期: | 04/30/2008 |
预计主要完成日期: | 07/31/2008 |
预计完成日期: | 07/31/2008 |
状况或疾病
干预/治疗
Drug: 1
Drug: 2
Drug: 3
相
手臂组
臂 | 干预/治疗 |
---|---|
Active Comparator: 1 | Drug: 1 Each patient will receive one 250 ml dose. |
Experimental: 2 | Drug: 2 Each patient will receive one 250 ml dose. |
Experimental: 3 | Drug: 3 Each patient will receive one 250 ml dose. |
资格标准
有资格学习的年龄 | 5 Years 至 5 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Children 5-10 years of age evaluated in The Hospital for Sick Children's emergency department Exclusion Criteria: - Children with diarrhea, a vomiting or diarrhea episode within 24 hours, head trauma, abdominal pain, upper respiratory symptoms, or nil per os status - Patients with gastrointestinal symptoms |
结果
主要结果指标
1. Mean taste scores for Pedialyte, Pediatric Electrolyte, and Enfalyte. [Immediately following consumption of each solution.]
次要成果指标
1. Proportions of children who indicate a taste preference for one of the solutions. [Immediately following consumption of each solution.]