Paracetamol vs Metoclopramide on Postoperative Nausea and Vomiting
关键词
抽象
描述
One hundred-twenty patients are randomly divided into two groups; the paracetamol group who received the IV infusion of paracetamol (1.5 ml/kg); and the metoclopramide group who received the IV infusion of metoclopramide (0.2 mg/kg) in saline. The presence of vomiting and the actions indicative of nausea, such as repeated gagging or spitting, within 24h following general anesthesia are defined as PONV. All PONV episodes and postoperative pain scores are recorded during 24h postoperatively. The postoperative 0-4h and 4-24h are defined as early and late postoperative period, respectively. Intravenous 4 mg ondansetron as rescue antiemetic drug is administered in case of two or more vomiting episodes.
日期
| 最后验证: | 06/30/2018 |
| 首次提交: | 07/04/2018 |
| 提交的预估入学人数: | 07/04/2018 |
| 首次发布: | 07/16/2018 |
| 上次提交的更新: | 07/04/2018 |
| 最近更新发布: | 07/16/2018 |
| 实际学习开始日期: | 07/19/2018 |
| 预计主要完成日期: | 08/19/2018 |
| 预计完成日期: | 08/20/2018 |
状况或疾病
干预/治疗
Drug: Perfalgan
Drug: Metoclopramide
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Active Comparator: Perfalgan 1.5 mg/kg intravenous, intraoperative (20 min before end of the surgery) | |
| Active Comparator: Metoclopramide 0.2 mg/kg intravenous, intraoperative (20 min before end of the surgery) |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - ASA (the classification of the American Society of Anesthesiologists) physical status I-II - Patients who scheduled for elective maxillofacial surgery under general anesthesia Exclusion Criteria: - Patients with a history of allergy to any of the study medications (opioid, general anesthetic agents or paracetamol) - History of opioid use, hepatic or renal disease, coronary, psychotic and neurologic diseases - Use of antiemetic, antihistaminic, analgesic or corticosteroid 24 hours (h) prior to surgery |
结果
主要结果指标
1. Preventing of postoperative nausea and vomiting [First 24 hours postoperatively]
