Pathophysiology of Martorell Hypertensive Ischemic Leg Ulcer (HYTILU)
关键词
抽象
描述
Comparative study including
- 20 consecutive patients with Martorell HYTILU
- 10 consecutive patients with Calciphylaxis (calcific uremic arteriolopathy)
- 20 patients with venous ulcer
The following parameters are measured in the blood serum:
White blood count; c-reactive protein; creatinine; calcium (total); free (ionized) calcium; phosphate; albumin; 25-hydroxyvitamin-D; 1-25-dihydroxyvitamin-D; homocysteine; cystatin C alphafetoin, osteoprotegerin; fibroblast growth factor 23 (FGF-23); globular arrest 1 (GLA-1)
The following parameters are measured in samples of diseased (necrobiotic) skin:
alphafetoin, osteoprotegerin; fibroblast growth factor 23 (FGF-23); globular arrest 1 (GLA-1)
日期
| 最后验证: | 09/30/2016 |
| 首次提交: | 05/01/2011 |
| 提交的预估入学人数: | 04/12/2012 |
| 首次发布: | 04/15/2012 |
| 上次提交的更新: | 10/26/2016 |
| 最近更新发布: | 10/27/2016 |
| 实际学习开始日期: | 08/31/2011 |
| 预计主要完成日期: | 11/30/2018 |
| 预计完成日期: | 11/30/2018 |
状况或疾病
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Hypertensive ischemic leg ulcer Twenty consecutive patients with Martorell HYTILU as defined in:
Arch Dermatol 2010;146:961-968 | |
| Calciphylaxis Ten subjects with calciphylaxis (calcific uremic arteriolopathy) as described in:
Vasa 1998;27:137-143 | |
| Venous ulcer (controls) Twenty subjects with venous ulcers (CEAP C4-6) as described in:
J Vasc Surg. 2004 Dec;40(6):1248-52 |
资格标准
| 有资格学习的年龄 | 20 Years 至 20 Years |
| 有资格学习的性别 | All |
| 取样方式 | Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Having Martorell hypertensive ischemic leg ulcer (as defined above) or - Having Calciphylaxis (calcific uremic arteriolopathy (as defined above) or - Having a venous ulcer (as defined above) Exclusion Criteria: - None |
结果
主要结果指标
1. Martorell HYTILU and calciphylaxis show both decreased tissue protection mechanisms against tissue calcification [36 months]
次要成果指标
1. Martorell hypertensive ischemic leg ulcer and calciphylaxis are both characterized by non-infectious inflammation [36 months]
