Penehyclidine and Postoperative Nausea and Vomiting After Bimaxillary Surgery
关键词
抽象
描述
Postoperative nausea and vomiting (PONV) are one of the most frequent complications after surgery, and are associated with patients' dissatisfaction after anesthesia and surgery. Orthognathic surgery is widely performed for the correction of dentofacial deformities. PONV is common after orthognathic surgery. Despite of improved anti-emetic prophylaxis, patients undergoing orthognathic surgery are reported to have a high incidence of PONV, especially those after bimaxillary surgery.
It is known that activation of central cholinergic system plays an important role in the development of PONV. Muscarinic antagonists such as scopolamine can block muscarinic receptors in the cerebral cortex and produce anti-emetic effects. Penehyclidine is a new muscarinic antagonists which selectively block M1 and M3 receptors. It has fewer adverse effects compared with other anticholinergics. The purpose of this retrospective cohort study is to investigate whether use of penehyclidine is associated with a reduce risk of PONV in patients undergoing bimaxillary surgery.
日期
| 最后验证: | 05/31/2020 |
| 首次提交: | 09/26/2019 |
| 提交的预估入学人数: | 09/29/2019 |
| 首次发布: | 10/01/2019 |
| 上次提交的更新: | 06/25/2020 |
| 最近更新发布: | 06/29/2020 |
| 实际学习开始日期: | 10/06/2019 |
| 预计主要完成日期: | 12/29/2019 |
| 预计完成日期: | 12/29/2019 |
状况或疾病
干预/治疗
Drug: Penehyclidine group
Other: Placebo group
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Penehyclidine group Penehyclindine hydrochloride was administered before anesthesia induction. | Drug: Penehyclidine group Penehyclidine hydrochloride was administered before anesthesia induction. |
| Placebo group Penehyclindine hydrochloride was not administered before anesthesia induction. | Other: Placebo group Penehyclidine hydrochloride was not administered before anesthesia induction. |
资格标准
| 有资格学习的年龄 | 16 Years 至 16 Years |
| 有资格学习的性别 | All |
| 取样方式 | Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Age ≥16 years; - Underwent elective bimaxillary surgery under general anesthesia. Exclusion Criteria: - Age <16 years; - Missing data. |
结果
主要结果指标
1. Postoperative nausea and vomiting (PONV) within 48 hours after bimaxillary surgery. [Up to 48 hours after surgery.]
次要成果指标
1. Daily prevalence of PONV. [Up to 48 hours after surgery.]
2. Postoperative agitation after bimaxillary surgery. [Up to 8:00 am on the first day after surgery.]
3. Postoperative pain after bimaxillary surgery. [Up to 2 days after surgery.]
4. Postoperative complications during hospital stay after surgery. [Up to 30 days after surgery.]
5. Length of stay in hospital after surgery. [Up to 30 days after surgery.]
6. In-hospital mortality after surgery. [Up to 30 days after surgery.]
