Pharmacokinetics and Pharmacodynamics of Fructose
关键词
抽象
描述
Fructose consumption has risen sharply during the past several decades. Since its introduction to the United States in 1967, high fructose corn syrup (HFCS) has overtaken sucrose as the main sweetener in manufactured foods and beverages, and thus, is responsible for the approximately 30% increase in fructose in our diet. Numerous studies have shown that excessive fructose consumption can cause a variety of harmful metabolic effects, suggesting that fructose may partially be responsible for the current epidemic in obesity, hypertension, metabolic syndrome, and diabetes.
This preliminary study will investigate the pharmacokinetics and pharmacodynamics of fructose in a broad population. Specifically, the goal of our research are to compare the impact of the two main sources of dietary fructose, sucrose versus HFCS, on fructose bioavailability and acute metabolic changes by measuring response phenotypes, such as serum uric acid, lactate, and triglyceride levels.
日期
| 最后验证: | 09/30/2011 |
| 首次提交: | 04/15/2008 |
| 提交的预估入学人数: | 04/16/2008 |
| 首次发布: | 04/20/2008 |
| 上次提交的更新: | 02/13/2012 |
| 最近更新发布: | 02/15/2012 |
| 实际学习开始日期: | 02/29/2008 |
| 预计主要完成日期: | 07/31/2010 |
| 预计完成日期: | 07/31/2010 |
状况或疾病
干预/治疗
Other: Public
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Public General public. Those who are not currently taking any medication besides birth control pills. | Other: Public Comparison of different formulations of fructose. |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 取样方式 | Non-Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - adult subjects aged 18 years or older - either gender - any ethnicity - willing to abstain from drinking any alcohol 3 days prior to a study visit Exclusion Criteria: - history of liver or kidney disease - history of diabetes mellitus or fasting blood glucose ≥ 126 mg/dl or random blood glucose ≥ 200 mg/dl - currently taking any medication (except oral contraceptives) - consume more than 1 alcoholic drink per day - pregnant or breast-feeding - blood donor in the previous 8 weeks - history of gout |
结果
主要结果指标
1. Fructose [baseline, 15min, 30 min, 60 min, 90 min, 2 hr, 3 hr, 4.5 hr, 6 hr]
次要成果指标
1. serum uric acid [baseline, 15 min, 30 min, 60 min, 90 min, 2 hr, 3 hr, 4.5 hr, 6 hr]
2. glucose [baseline, 15 min, 30 min, 60 min, 90 min, 2 hr, 3 hr, 4.5 hr, 6 hr]
3. lactate [baseline, 15 min, 30 min, 60 min, 90 min, 2 hr, 3 hr, 4.5 hr, 6 hr]
4. triglycerides [baseline, 15 min, 30 min, 60 min, 90 min, 2 hr, 3 hr, 4.5 hr, 6 hr]
