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Pilot Study on the Tolerability of Dietary Dried Plum

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University of California, San Francisco

关键词

抽象

Dried plums (Prunus domestica L.) have traditionally been recognized for their health benefits related to conditions such as constipation, irregular menstrual cycles and mouth sores. This dried fruit provides high levels of fiber, vitamins and minerals. Dried plum has also been shown in animal studies to have beneficial effects on bone and can prevent the loss of bone caused by low hormone levels such as occurs after surgical removal of the ovaries. We also have shown that dried plum can prevent the loss of bone associated with aging in mice. Very few therapies for osteoporosis actually reverse bone loss and improve bone strength. The potential therapeutic value of dried plum in men and women with hormone deficiency or age-related osteoporosis is clear.

日期

最后验证: 01/31/2020
首次提交: 12/15/2009
提交的预估入学人数: 12/15/2009
首次发布: 12/17/2009
上次提交的更新: 02/25/2020
最近更新发布: 03/01/2020
实际学习开始日期: 11/30/2009
预计主要完成日期: 08/31/2010
预计完成日期: 08/31/2010

状况或疾病

Healthy
Elderly

干预/治疗

Dietary Supplement: dried plum

-

手臂组

干预/治疗
Experimental: dried plum
subjects will have 25% by weight (~ 600 kcal if eat 2500 kcal diet) of their usual diet substituted by dried plum powder
Dietary Supplement: dried plum
subjects will have 25% of their diet substituted by dried plum powder

资格标准

有资格学习的年龄 50 Years 至 50 Years
有资格学习的性别All
接受健康志愿者
标准

Inclusion Criteria:

- Age between 50 yrs and 75 yrs

- Nonsmokers

- Normal renal and hepatic function

Exclusion Criteria:

- Subjects who must follow a specific diet

- Subjects on any daily medications that affect bone health

- Subjects too heavy for the DEXA machine (weight limit 300 lbs)

- Subjects whose BMD by DEXA indicates osteoporosis

- Subjects unwilling to follow the diet specified

- Pregnant women

- Subjects who are unable to understand the consent form.

结果

主要结果指标

1. urinary calcium excretion [one month]

次要成果指标

1. ability to tolerate the diet [one month]

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