Pilot Study on the Tolerability of Dietary Dried Plum
只有注册用户可以翻译文章
登陆注册
链接已保存到剪贴板
状态已完成
赞助商
University of California, San Francisco
临床试验: NCT01035372
BioSeek: nct01035372
关键词
抽象
Dried plums (Prunus domestica L.) have traditionally been recognized for their health benefits related to conditions such as constipation, irregular menstrual cycles and mouth sores. This dried fruit provides high levels of fiber, vitamins and minerals. Dried plum has also been shown in animal studies to have beneficial effects on bone and can prevent the loss of bone caused by low hormone levels such as occurs after surgical removal of the ovaries. We also have shown that dried plum can prevent the loss of bone associated with aging in mice. Very few therapies for osteoporosis actually reverse bone loss and improve bone strength. The potential therapeutic value of dried plum in men and women with hormone deficiency or age-related osteoporosis is clear.
日期
最后验证: | 01/31/2020 |
首次提交: | 12/15/2009 |
提交的预估入学人数: | 12/15/2009 |
首次发布: | 12/17/2009 |
上次提交的更新: | 02/25/2020 |
最近更新发布: | 03/01/2020 |
实际学习开始日期: | 11/30/2009 |
预计主要完成日期: | 08/31/2010 |
预计完成日期: | 08/31/2010 |
状况或疾病
Healthy
Elderly
干预/治疗
Dietary Supplement: dried plum
相
-
手臂组
臂 | 干预/治疗 |
---|---|
Experimental: dried plum subjects will have 25% by weight (~ 600 kcal if eat 2500 kcal diet) of their usual diet substituted by dried plum powder | Dietary Supplement: dried plum subjects will have 25% of their diet substituted by dried plum powder |
资格标准
有资格学习的年龄 | 50 Years 至 50 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Age between 50 yrs and 75 yrs - Nonsmokers - Normal renal and hepatic function Exclusion Criteria: - Subjects who must follow a specific diet - Subjects on any daily medications that affect bone health - Subjects too heavy for the DEXA machine (weight limit 300 lbs) - Subjects whose BMD by DEXA indicates osteoporosis - Subjects unwilling to follow the diet specified - Pregnant women - Subjects who are unable to understand the consent form. |
结果
主要结果指标
1. urinary calcium excretion [one month]
次要成果指标
1. ability to tolerate the diet [one month]