Primary Ovarian Insufficiency, Polycystic Ovary Syndrome & the CardiOvascular Risk Profile
关键词
抽象
描述
Cardiovascular risk profile will be assessed in women with PCOS and POI > 45 years of age, consisting of:
fasting serum and urine analyses blood pressure, length, weight, waist circumference, hip circumference ECG carotid intima media thickness cardiac ultrasound
spare serum, plasma and urine will be stored in -80 degrees celsius biobank.
日期
| 最后验证: | 11/30/2018 |
| 首次提交: | 11/19/2015 |
| 提交的预估入学人数: | 11/23/2015 |
| 首次发布: | 11/29/2015 |
| 上次提交的更新: | 12/09/2018 |
| 最近更新发布: | 12/10/2018 |
| 实际学习开始日期: | 06/30/2013 |
| 预计主要完成日期: | 11/30/2017 |
| 预计完成日期: | 11/30/2017 |
状况或疾病
干预/治疗
Procedure: cardiovascular screening
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| PCOS Rotterdam criteria (at least 2 out of three criteria present) oligo-anovulation polycystic ovarian morphology hyperandrogenism | |
| POI amenorrhea of at least 4 months prior to age 40 years, with follicle stimulating hormone (FSH) levels above 40 IU/L |
资格标准
| 有资格学习的年龄 | 45 Years 至 45 Years |
| 有资格学习的性别 | Female |
| 取样方式 | Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - age above 45 years Exclusion Criteria: - none |
结果
主要结果指标
1. carotid intima media thickness [10 years post diagnosis]
次要成果指标
1. dyslipidemia [10 years post diagnosis]
2. insulin and glucose levels [10 years post diagnosis]
3. C-reactive protein [10 years post diagnosis]
4. homocysteine [10 years post diagnosis]
5. uric acid [10 years post diagnosis]
6. androgen levels [10 years post diagnosis]
7. electrocardiogram (ECG) [10 years post diagnosis]
8. cardiac ultrasound (hypertrophy) [10 years post diagnosis]
