Propofol and Dexmedetomidine on Inflammation
关键词
抽象
描述
Dexmedetomidine, was reported to prevent postoperative delirium in elderly patients following its use in intensive care units. Possible mechanisms included improved quality of sleep and an inhibitory effect on inflammation. A greater number of studies indicated that propofol has negative effect on postoperative cognitive function. In this study, patients who will receive hip and knee arthroplasty will be divided to two groups: Propofol group and Dexmedetomidine group. Spinal anesthesia will be used to meet the requirement of intraoperative analgesia. Patients in two groups will be sedated by propofol and dexmedetomidine, respectively. TNF-α and IL-6 in blood will be detected. And postoperative cognitive function of patients will be investigated. The objective of this study is to clarify the influence of these two different sedative drugs on peripheral inflammation induced by surgery, and the relationship with the change of postoperative cognitive function.
日期
| 最后验证: | 03/31/2018 |
| 首次提交: | 06/26/2018 |
| 提交的预估入学人数: | 07/15/2018 |
| 首次发布: | 07/25/2018 |
| 上次提交的更新: | 07/15/2018 |
| 最近更新发布: | 07/25/2018 |
| 实际学习开始日期: | 07/31/2018 |
| 预计主要完成日期: | 08/31/2018 |
| 预计完成日期: | 11/30/2018 |
状况或疾病
干预/治疗
Drug: Propofol group
Drug: Dexmedetomidine group
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: Propofol group Patients in this arm will be sedated by propofol. | Drug: Propofol group Propofol will be used to offer intraoperative sedation for patients in Propofol group. |
| Experimental: Dexmedetomidine group Patients in this arm will be sedated by dexmedetomidine. | Drug: Dexmedetomidine group Dexmedetomidine will be used to offer intraoperative sedation for patients in Dexmedetomidine group. |
资格标准
| 有资格学习的年龄 | 65 Years 至 65 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - The patients included in this study were 65 years or older, were undergoing total hip arthroplasty, and were classified as American Society of Anesthesiologists (ASA) physical health class I-IV. Exclusion Criteria: - Contraindications to spinal anesthesia (i.e., coagulopathy, concurrent use of anticoagulants, infection at puncture site, and refusal of spinal anesthesia), patients with infectious diseases, patients with mental or language barriers, patients who had been anesthetized within the past 30 days, severe congestive heart failure (New York Heart Association, class IV) and/or severe chronic obstructive pulmonary disease (Global Initiative for Chronic Obstructive Lung Disease Guidelines, stages III-IV), sick sinus syndrome, severe sinus bradycardia (< 50 beats per min), and second or greater atrioventricular block without pacemaker. In addition, patients exhibiting cognitive impairment (i.e., a Mini-Mental State Examination (MMSE) score < 24) and/or preoperative delirium (i.e., positive Confusion Assessment Method (CAM) result) were excluded. |
结果
主要结果指标
1. change of the concentration of IL-6 [Preoperative and end of surgery]
次要成果指标
1. Postoperative delirium [Postoperative (1-3 days after surgery)]
2. Postoperative cognitive dysfunction [Postoperative (7 and 30 days after surgery)]
3. change of the concentration of TNF-α [Preoperative and end of surgery]
