Protocol PERCAF 2018
关键词
抽象
描述
Coffee is the most consumed arousing substance in the world. Caffeine is used as a natural countermeasure to maintain the performance of sleep deprived subjects. However, the effectiveness of caffeine is characterized by a large individual variability, also observed on side effects. This variability could notably be related to polymorphisms of the adenosine receptor 2a gene (ADORA2A) and Tumor Necrosis Factor-alpha, a pro-inflammatory cytokine whose increase is observed during sleep deprivation.
This study, under conditions of total sleep deprivation in the laboratory (40 hours of continuous awakening), examine the cross-influence of two polymorphisms (ADORA2A: rs5751876 and TNF-alpha: rs1800629) on the sensitivity to caffeine and on the degradation of attentional performances. Physical performance, mental performance, immuno-inflammatory responses and the occurrence indesirable effects will be evaluate.
This work aims to understand the mechanisms that contribute to increasing individual vulnerability and promoting protective countermeasures. The purpose of this project is to improve the recommendations concerning the daily use of caffeine and during periods of prolonged awakening, particularly in the military environment.
日期
最后验证: | 04/30/2019 |
首次提交: | 02/24/2019 |
提交的预估入学人数: | 02/27/2019 |
首次发布: | 02/28/2019 |
上次提交的更新: | 05/17/2019 |
最近更新发布: | 05/20/2019 |
实际学习开始日期: | 09/01/2018 |
预计主要完成日期: | 09/02/2018 |
预计完成日期: | 06/25/2019 |
状况或疾病
干预/治疗
Other: Sleep deprivation
相
手臂组
臂 | 干预/治疗 |
---|---|
Experimental: Caffeine Caffeine 5 mg/kg/day in 2 administration (08:00 and 14:00) per day | |
Placebo Comparator: placebo in 2 administration (08:00 and 14:00) per day |
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - healthy subject Exclusion Criteria: - Treatment - History of cardiovascular, psychiatric, pneumologic, haematologic, cancerology disease - Nonvoluntary - Pregnancy |
结果
主要结果指标
1. Psychomotor vigilance test Speed [Change from Baseline Psychomotor vigilance test Speed at day 2 after 24 hours awaking]
次要成果指标
1. Cognitive performance [Change from Baseline at day 2 after 25 hours awaking]
2. Force -velocity [Change from Baseline at day 2 after 32 hours awaking]