Resveratrol's Effects in Diabetic Nephropathy
关键词
抽象
描述
Diabetes mellitus (DM) is one of the most important public health burdens, and its prevalence has rapidly increased worldwide over the past decades. One of the most important complications of DM is nephropathy.
Resveratrol (3, 5, 4'-trihydroxystilbene) is a natural polyphenolic compound belongs to the large group of polyphenols found in different plant species. The richest natural source of resveratrol is Polygonum cuspidatum — a plant root extract of which have been used in oriental folk medicine. Considerable amounts of resveratrol were also found in skin of red grapes, peanuts, groundnuts, and red vine.
Resveratrol is considered to have beneficial effects on glucose tolerance and insulin sensitivity, the cardiovascular system, as it has been found to improve vasodilatation, ischaemic preconditioning, both of which seem to be the result of the activation of the endothelial NO synthase enzyme, and to inhibit both platelet aggregation and vascular smooth muscle cell proliferation. Resveratrol itself is an efficient antioxidant, as evidenced by both in vitro and in vivo studies, and, it has also been shown to improve diabetes-related impairments in animals.
We hypothesized that resveratrol may have a favorable effects on control of diabetic nephropathy. The aim of this study is to evaluate the safety and effects of resveratrol in treatment of diabetic nephropathy.
日期
最后验证: | 09/30/2017 |
首次提交: | 03/03/2016 |
提交的预估入学人数: | 03/05/2016 |
首次发布: | 03/09/2016 |
上次提交的更新: | 10/02/2017 |
最近更新发布: | 10/04/2017 |
实际学习开始日期: | 02/29/2016 |
预计主要完成日期: | 01/31/2017 |
预计完成日期: | 01/31/2017 |
状况或疾病
干预/治疗
Drug: Resveratrol
Drug: Placebo
Drug: Losartan
相
手臂组
臂 | 干预/治疗 |
---|---|
Experimental: Resveratrol Resveratrol + Losartan | Drug: Resveratrol Resveratrol 500mg daily |
Placebo Comparator: Placebo Placebo + Losartan | Drug: Placebo Placebo 1 capsule daily |
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - Type 2 diabetes mellitus (DM) - Controlled blood sugar [fasting blood sugar (FBS) <130mg/dl and glycosylated hemoglobin (A1C)<7% - Urine albumin >20mg/lit in two separate occasions during the last 3 months period - Serum creatinin < or = 2mg/dl Exclusion Criteria: - Pregnancy - Lactation - Alcoholism - Liver failure (acute or chronic) - Renal failure: serum creatinin >2mg/dl - Glomerulonephritis - Uncontrolled hypertension - Congestive heart failure - Prostate disease - Malignancy - Bilateral renal artery stenosis - Any systemic disease other than DM - Any infection or rheumatologic disorder - Use of warfarin |
结果
主要结果指标
1. Urine albumin level [3 months]
2. Serum creatinin [3 months]
次要成果指标
1. Fasting blood sugar (FBS) [3 months]
2. Glycosylated hemoglobin (A1C) [3 months]
3. Liver aminotransferases (ALT and AST) [3 months]
4. Serum insulin level [3 months]
5. Number of patients with adverse events [3 months]