Retinol on Human Skin Aging in East Asian Descent
关键词
抽象
日期
| 最后验证: | 02/28/2019 |
| 首次提交: | 02/25/2016 |
| 提交的预估入学人数: | 09/13/2016 |
| 首次发布: | 09/19/2016 |
| 上次提交的更新: | 03/24/2019 |
| 最近更新发布: | 04/15/2019 |
| 首次提交结果的日期: | 02/26/2019 |
| 首次提交质量检查结果的日期: | 03/24/2019 |
| 首次发布结果的日期: | 04/15/2019 |
| 实际学习开始日期: | 10/31/2015 |
| 预计主要完成日期: | 03/08/2018 |
| 预计完成日期: | 03/08/2018 |
状况或疾病
干预/治疗
Drug: Older Group Ages 55-75
Drug: Older Group Ages 55-75
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Other: Older Group Ages 55-75 Active and Placebo. Participants received retinol lotion on one arm and placebo to match on the other arm. | Drug: Older Group Ages 55-75 Retinol in the form of vitamin A lotion |
| No Intervention: Young Group Ages 18-25 Participants in the group will give tissue sample only for comparison. |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | Female |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - able to provide written informed consent - older group: age between 50 and 75 years - young group: age 18 to 25 years - all four grandparents of Han Chinese, Japanese, Korean descent - body mass index within normal or overweight range - no history of weight loss of >20 lbs within past 5 years Exclusion Criteria: - skin condition in the areas of skin biopsy that would obscure results of analysis - topical creams or treatment to arms 2 weeks prior to study baseline visit - individuals with known hypersensitivity to retinoid class of agents (older group only) - prior anti-aging treatments to arms including retinol, microdermabrasion within 2 weeks of baseline visit - prior laser therapy or surgical procedure to arms - prior radiation or other trauma (extensive burns or abrasions) to arm skin - hormone-based therapy within 4 weeks of enrollment |
结果
主要结果指标
1. Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Older Group, Retinol Versus Placebo) [Week 12]
2. Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Younger Group Versus Older Group as Baseline) [Week 1]
次要成果指标
1. Transepidermal Water Loss [Baseline; Week 12]
2. Severity of Arm Skin Wrinkling [Baseline; Week 12]
3. Elasticity on Arm Skin [Baseline; week 12]
4. Count of Participants With Skin and Subcutaneous Adverse Events as a Measure of Type and Severity of Adverse Events [Baseline through week 12]
